Results 71 to 80 of about 8,530,343 (302)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Lack of clear standards and usable comparisons of downscaled climate projections pose a roadblock for US climate discovery and adaptation

Environmental Research Letters
The release of global climate projections coupled with the demand for local-resolution climate-forced meteorology has prompted many research groups to downscale these projections using various statistical, dynamical, and current machine learning ...
Samantha H Hartke, Andrew J Newman, Ethan D Gutmann, Rachel R McCrary, Nicholas D Lybarger, Flavio Lehner, Andrew W Wood, Jeffrey R Arnold, Keith W Dixon   +8 more
doaj   +1 more source

Information Needs of Rural Communities

The Journal of Community Informatics, 2012
Accessing required information via the Internet is becoming significant to improve the quality of life. The purpose of this study is to identify the information needs of rural communities. Fieldworks were carried out involving surveys, interviews and observations.
Nor Iadah Yusop, Huda Ibrahim, Shafiz Affendi Mohd. Yusof, Zahurin Mat Aji, Zulkhairi Md. Dahalin, Osman Ghazali, Mohd. Nizam Saad, Mohamad Amir Abu Seman, Azman Yasin, Khairudin Kasiran, Rafidah Abd. Razak   +10 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Community Health Nursing in Saudi Arabia: Practices and Learning Needs [PDF]

Khalid Abdullah Aljohani Nursing College, Taibah University, Madinah, Saudi ArabiaCorrespondence: Khalid Abdullah Aljohani, Email aljohani.khalid@gmail.comPurpose: This study investigated the daily practices of community nurses working in Primary Health ...
Aljohani KA
core  

Community agency, needs mapping and solidarity economics in resource depleted communities [PDF]

, 2019
Against the backdrop of shrinking budgets for most social welfare departments in most of sub Saharan Africa, there is a shortfall of essential services.
Che, C.
core  

Unearthing how Jamaican secondary students have made sense of the traditional meanings of academic performance and academic success

International Journal of Adolescence and Youth
The Caribbean Examinations Council data from 2011 to 2021 for the Caribbean Secondary Examination Certificate (CSEC) Council (2011–2021) shows many Jamaican secondary students failing to pass the Mathematics and English examinations.
Khummit Keshinro, Cathy Tissot, Catherine Foley   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source