Results 51 to 60 of about 10,571,749 (304)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Evaluation of community health service center training base by Shanghai hospice care competent nurse trainees: a qualitative study

BMC Palliative Care
Background Enhancing the training of competent nurses in hospice care helps improve the quality of life for end-of-life care patients. The purpose of these interviews was to assess the quality of teaching and the adequacy of logistical support (including
Yanjun Huang, Gan Wang, Xinyu Li, Yuezhong Tang, Zhijie Yu, Wen Chen   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A curcumin-enabled ZIF8 nanosystem enables ovarian cancer treatment by inducing mitochondrial disruption

Discover Nano
Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging.
Zhishan Zhang, Genghui Luo, Xiaoxia Tang, Xiubin Ma, Weitao Huang, Bin Wang, Xueying Meng, Caiyan He, Xiaoman Cai, Ping Zhang, Shiyou Luo   +10 more
doaj   +1 more source

Evaluation of the BronchiolitisMAD protocol in the out-of-hospital emergency services of the Community of Madrid

Emergency Care Journal
The objective of this study was to evaluate the BronchiolitisMAD protocol after its implementation in the out-of-hospital emergency services (OHES) of the Autonomous Community of Madrid (ACM), assessing the clinical improvement during the transfer ...
Beatriz Jiménez-Sánchez Carpio, Laura Sánchez-García, Itziar Marsinyach-Ros, Joaquín Antonio Rendo-Murillo, Víctor Quesada-Cubo, Marina Gómez-Morán Quintana, Jorge Lorente-Romero, María Isabel Sánchez-Sáenz, Ana María Cintora-Sanz, Cristina Horrillo-García   +9 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

The Impacts of International Political and Economic Events on Japanese Financial Markets

International Journal of Financial Studies, 2020
Information about the possibilities of changes in national and international macroeconomic variables affects the expectations and behavior of individuals and firms more quickly than real changes in those macroeconomic variables.
Mirzosaid Sultonov
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Insufficient knowledge and moderate attitudes and practices regarding continuous glucose monitoring among patients with diabetes

Scientific Reports
Continuous glucose monitoring (CGM) has shown increasing application in diabetes management. This study aimed to explore the knowledge, attitudes, and practices (KAP) of patients with various types of diabetes towards CGM.
Feng Zhang, Zhenyuan Tang, Yating Ma, Yunle Zhang, Pingping Liang, Lianfeng Yang, Li Wang   +6 more
doaj   +1 more source