Results 51 to 60 of about 534,728 (260)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundCardiovascular-kidney-metabolic (CKM) syndrome reflects the interplay among metabolic risk factors, chronic kidney disease, and cardiovascular disease (CVD).
Huiyi Liu +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Taxifolin attenuates monocrotaline-induced experimental pulmonary arterial hypertension by regulating leukocyte chemotaxis and Ackr receptors [PDF]
Jichu yixue yu linchuangObjective To investigate the therapeutic effect of the natural flavonoid taxifolin in experimental pulmonary arterial hypertension (PAH), and to further explore its potential molecular mechanisms underlying the amelioration of PAH.
LIU Qiwei, LI Ni, ZHANG Haobing, ZHANG Hong, SONG Wanlu, HU Yufei, YANG Peiran
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Disparities in multiple chronic conditions within populations [PDF]
, 2013 Disadvantaged populations are disproportionately affected by multiple chronic conditions (MCCs), yet few studies examine the prevalence, outcomes, or effectiveness of MCC interventions in minority and socioeconomically deprived individuals and ...
Efrat Shadmi RN, PhD, Shadmi, Efrat
core +1 more source
Chinese expert consensus on disclosure of sudden unexpected death in epilepsy
Chinese Journal of Contemporary Neurology and NeurosurgerySudden unexpected death in epilepsy (SUDEP) refers to the sudden, unexpected, and witnessed or unwitnessed death of a patient with epilepsy, with or without evidence of a seizure, excluding status epilepticus, non-traumatic and non-drowning causes, and ...
Comorbidity Committee of China Association Against Epilepsy
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Prevalence of disability according to multimorbidity and disease clustering: a population-based study [PDF]
, 2011 Background: The prevalence of chronic diseases has increased with population ageing, and research has attempted to elucidate the correlation between chronic diseases and disability. However, most studies in older populations have focused on the effect of
Marengoni, Alessandra +4 more
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