Results 71 to 80 of about 228,337 (250)

Évaluation de l’inadéquation éducative effective à partir de données du PIAAC

Revue Internationale du Travail
Les auteurs mesurent l’inadéquation éducative en mobilisant une nouvelle définition, qui tient compte de l’hétérogénéité des compétences à niveau d’études identique.
doaj   +2 more sources

Sens, construction et mise en œuvre de l'évaluation des compétences : une étude de cas dans une classe d'un collège parisien [PDF]

, 2010
https://plone2.unige.ch/aref2010International audienceAvec la prescription du socle commun, l'approche par les compétences est imposée dans le système éducatif sans que les enseignants ne soient spécifiquement formés à sa mise en oeuvre. La communication
Gaime, Elvire, Younes, Nathalie
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Evaluation des futurs enseignants des SVT du Centre Régional des Métiers de l'Education et de la Formation de Meknès en formation pratique : Réalité et perspectives

Moroccan Journal of Quantitative and Qualitative Research, 2019
La formation des futurs enseignants est fondée sur l'articulation entre deux espaces : Centre Régional des Métiers de l'Education et de la Formation "CRMEF" et l'établissement de pratique.
A. Eddif, S. Selmaoui, R. Chakour
doaj   +1 more source

Etude Sur la Stratégie et le Programme D'appui à la Société Civile Burundaise [PDF]

, 2002
The author study's strategies and programs to build civil society in ...
Christophe Sebudandi, Gérard Nduwayo
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Information imparfaite [PDF]

Nous tenterons, dans cet article, de clarifier les enjeux de l'intégration de l'information imparfaite dans les principales analyses de la firme: l'analyse des coûts de transaction (section 1), la théorie des contrats incomplets (section 2) et l'approche
Jackie Krafft
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source