Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2012 April 15, 2012 issue of The Companion, a publication of the University of Scranton's University ...
University of Scranton. Campus Ministries
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Protocol for cell-specific ratiometric quantification of apoplastic pH in Arabidopsis seedlings. [PDF]
STAR ProtocXiong L, Mas P.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Companion February 5, 2012
, 2012 February 5, 2012 issue of The Companion, a publication of the University of Scranton's University ...
University of Scranton. Campus Ministries
core
Therapeutic Monoclonal Antibodies as Advanced Therapies for Companion Animals: Species Adaptation, Fc Biology, Clinical Translation, and Future Platforms. [PDF]
Vet SciFu Y, Guo Z, Wang H.
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2012 May 13, 2012 issue of The Companion, a publication of the University of Scranton's University ...
University of Scranton. Campus Ministries
core
Dietary Reactive Oxygen Species and Oxidative Stress: Pathogenic Mechanisms Linking Food and Feed Exposure to Disease in Humans and Companion Animals. [PDF]
Biology (Basel)Park HJ, Kim HM.
europepmc +1 more source