Results 221 to 230 of about 8,677,105 (298)

Estimating Longitudinal Changes in Workday Happiness From Daily Report Texts Among Employees: Retrospective Feasibility Study. [PDF]

JMIR Form Res
Hayashi J, Ito K, Manabe M, Watanabe Y, Nakayama M, Uchida Y, Wakamiya S, Aramaki E.   +7 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Unusual Hemodynamic Presentation of Pediatric Kikuchi-Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor-Dependent Hypotension. [PDF]

Clin Case Rep
Alfraij A, Mothafar F, Alfadhli W, Ashkanani A, Kamal LA, Redha E, Aldaithan A.   +6 more
europepmc   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Abemaciclib plus endocrine therapy in HR-positive, HER2-negative high-risk early breast cancer: efficacy in nodal subgroups. [PDF]

ESMO Open
Cortes J, Johnston SRD, Martin M, Tolaney SM, Goetz MP, Rugo HS, Sohn J, Ozyilkan O, Abreu MH, Zaiss M, Vianna KM, Nielsen HM, Chan A, Kalofonos H, Morales S, Grimes BR, Amdur S, Neven P.   +17 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Why Prioritize Personal Gain Over Principles? The Relationship Between Calculative Mindset, Moral Disengagement, and Ethical Compromise. [PDF]

Psych J
Wang S, Sun X, Hu K, Wu M.
europepmc   +1 more source

Dual‐Functional Membranes With Interfacial MXene/PFSA Nanoarchitectures for Low Hydrogen Permeation in Water Electrolysis and Reduced Vanadium Ion Crossover in Flow Batteries

Advanced Science, EarlyView.
A PFSA/MXene composite membrane is developed for both PEMWE and VRFB applications. MXene incorporation simultaneously enhances proton conductivity and suppresses hydrogen/vanadium crossover. The interaction between MXene functional groups and PFSA's –SO3H reduces the proton diffusion barrier via hydrogen‐bonding networks, while the disordered ...
Panpan Guan, Mingjia Jiang, Yunhu Jiang, Wei Li, Yecheng Zou, Lixiao Zhang, Kaifeng Long, Ziqi Sun, Ting Liao, Hua Kun Liu, Ding Yuan, Dingsheng Wang, Shi Xue Dou, Yuhai Dou   +13 more
wiley   +1 more source

Patient Experiences of Chronic Low Back Pain: Development of a Conceptual Model Based on a Targeted Literature Review and Qualitative Patient Interviews. [PDF]

Musculoskeletal Care
Seçinti E, Klooster B, Robinson R, Bernstein MC, Tallarico M, Chatterton K, Voci A, Olonilua D, Linton SR, Litcher-Kelly L, Lagarde MMM, Wietecha LA, Markman J.   +12 more
europepmc   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source