Results 41 to 50 of about 9,257,649 (292)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Modeling Business-Processes of Digital Company

Вестник Российского экономического университета имени Г. В. Плеханова, 2022
The article studies digital companies, models business-processes and formulates growth spots of competitive advantages in conditions of digitalization.
I. V. Manakhova, E. V. Levchenko, A. R. Esina   +2 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Company characteristics affecting sustainability reporting disclosures. Evidence from United Arab Emirates

Cogent Business & Management
Guided by legitimacy theory and stakeholder theory, The purpose of this research is to investigate the effect of company characteristics, represented by company size, company sector, profitability, leverage, age, and state ownership, on sustainability ...
Fadi Ezat Jamaan
doaj   +1 more source

The Effect of Board Characteristics and Company Size on Tax Transparency [PDF]

پژوهش‌های تجربی حسابداری
The purpose of this research is to investigate the effect of board characteristics and company size on tax transparency. Tax transparency means properly measuring, presenting and disclosing the amount of tax in the financial statements. Tax transparency,
Azadeh Maddahi
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

[Stieff Piano Company store]

, 1905
From Sleeve: Stieff Piano Company. Branch Series. (14435). N645.Charles M. Stieff Piano Company, No. 9 Liberty Street, BALTIMORE, MDTitle supplied by cataloger.Positive digital file from original glass negative.Some paper adhered to emulsion, some spots ...
Hughes Company
core   +1 more source

The Link Between a Firm´s Internal Characteristics and Performance: GPTW & VRIO Dimension Analysis

Revista de Administração IMED, 2018
The following article addresses the models of Dr. Jay Barney, author of the article “Firm Resources and Sustained Competitive Advantage” and Robert Levering, author of the book “A Great Place to Work”, which deals with the internal characteristics of ...
José G. Vargas-Hernández, Francia Contreras Garcia   +1 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source