Results 51 to 60 of about 2,518,855 (308)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

FACTORS SHAPING CORPORATE SOCIAL DISCLOSURE PRACTICES: EVIDENCE FROM THE SAUDI ARABIAN CONTEXT

Modern Management Review
This research investigates factors influencing corporate social disclosure (CSD) within the context of Saudi Arabia. Specifically, it examines how corporate governance attributes and company characteristics impact the extent of CSD.
Ilyes CHARCHAFA, Bilal KIMOUCHE
doaj   +1 more source

Investment Characteristics of Natural Monopoly Companies [PDF]

Journal of Competitiveness, 2012
This paper explores the possibilities of investment by private investors in natural monopoly companies. The paper analyzes the broad issue of risk measurement with focus on downside risk measurement principle. The main scientific aim is to adopt a more sophisticated and theoretically advanced statistical technique and apply them to the findings.
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Company characteristics affecting sustainability reporting disclosures. Evidence from United Arab Emirates

Cogent Business & Management
Guided by legitimacy theory and stakeholder theory, The purpose of this research is to investigate the effect of company characteristics, represented by company size, company sector, profitability, leverage, age, and state ownership, on sustainability ...
Fadi Ezat Jamaan
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Weather Regimes of Extreme Wind Speed Events in Xinjiang: A 10–30 Year Return Period Analysis

Atmosphere
Xinjiang is a critical wind energy region in China. This study characterizes extreme wind speed (EWS) events in Xinjiang by using ERA5 reanalysis (1979–2023) and station observations (2022–2023).
Yajie Li, Dagui Liu, Donghan Wang, Sen Xu, Bin Ma, Yueyue Yu, Jianing Li, Yafei Li   +7 more
doaj   +1 more source

Substantial characteristics category "company restructuring" [PDF]

, 2011
Аналіз організаційних змін на промислових підприємствах Росії показує, що вибір і реалізація цілеспрямованого процесу керованої стратегічної реструктуризації вимагає обов'язкового пророблення методики (алгоритмів дій, методології й ін.) проведення ...
Гарина, Е. П.
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source