Results 91 to 100 of about 2,681,583 (289)

On the Validity of Value-at-Risk: Comparative Analyses with Expected Shortfall [PDF]

Value-at-risk (VaR) has become a standard measure used in financial risk management due to its conceptual simplicity, computational facility, and ready applicability. However, many authors claim that VaR has several conceptual problems.
Yamai, Yasuhiro, Yoshiba, Toshinao
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The complete mitochondrial genome of Engyodontium album and comparative analyses with Ascomycota mitogenomes

Genetics and Molecular Biology, 2017
Engyodontium album is a widespread pathogen that causes different kinds of dermatoses and respiratory tract diseases in humans and animals. In spite of its perniciousness, the basic genetic and molecular background of this species remains poorly ...
Xiao-Long Yuan, Xin-Xin Mao, Xin-Min Liu, Sen Cheng, Peng Zhang, Zhong-Feng Zhang   +5 more
doaj   +1 more source

Using entropy-based local weighting to improve similarity assessment [PDF]

, 2002
This paper enhances and analyses the power of local weighted similarity measures. The paper proposes a new entropy-based local weighting algorithm to be used in similarity assessment to improve the performance of the CBR retrieval task.
Comas, Joaquim, Cortés García, Claudio Ulises, Núñez, Héctor, Poch, Manel, Rodriguez-Roda, Ignasi, Sànchez-Marrè, Miquel   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

To the classification of the verbal idioms based on feelings expressed by them in Russian, Tajic and English languages

Polylinguality and Transcultural Practices, 2011
The article is devoted to the problem of classification of the verbal idioms. The comparative analyses conducted by the author in three languages results in identifying three categories of the verbal idioms expressing feelings.
F A Akhmedova
doaj  

Complete chloroplast genome sequence and phylogenetic analysis of Symphytum officinale [PDF]

Genetics and Molecular Biology
Symphytum officinale is a perennial herb belonging to the Boraginaceae. Here, we sequenced the complete chloroplast (cp) genomes of S. officinale using Illumina sequencing technology.
Yuemei Zhao, Xiaodan Chen, Tao Zhou, Rongxiang Zhang, Fang Zhao, Xiao Zhang   +5 more
doaj   +1 more source

Passenger cars taxation. Romania's case [PDF]

The paper presents the Romania tax framework concerning passenger cars taxation in a comparative manner in European context. This framework causes a lot of criticism from European officials and led to some reconsideration that shaped the actual form ...
Lazar, Sebastian
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source