Results 101 to 110 of about 1,657,556 (272)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Strengthening capacity for monitoring and evaluation through short course training in Kenya

African Evaluation Journal, 2017
Background: Weak monitoring and evaluation (M&E) systems and limited supply of M&E human resources in Africa signal the need to strengthen M&E capacity.
Hesborn Wao, Rohin Onyango, Elizabeth Kisio, Moses Njatha, Nelson O. Onyango   +4 more
doaj   +1 more source

Creation of public use files: lessons learned from the comparative effectiveness research public use files data pilot project [PDF]

, 2011
In this paper we describe lessons learned from the creation of Basic Stand Alone (BSA) Public Use Files (PUFs) for the Comparative Effectiveness Research Public Use Files Data Pilot Project (CER-PUF).
Erdem, Erkan, Prada, Sergio I
core  

A new paradigm evaluating cost per cure of HCV infection in the UK [PDF]

, 2016
Background: New interferon (IFN)-free treatments for hepatitis C are more effective, safer but more expensive than current IFN-based therapies. Comparative data of these, versus current first generation protease inhibitors (PI) with regard to costs and ...
Aline Gauthier, Elizabeth Holtham, Graham S. Cooke, Jeremie Schwarzbard, null null, Petar Atanasov, Stephen T. Barclay, William L. Irving   +7 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The TEAM (Trauma Evaluation and Management) course: medical student knowledge gains and retention in the USA versus Ghana

Trauma Surgery & Acute Care Open, 2019
Introduction Trauma and injury are significant contributors to the global burden of disease, with 5 million deaths and 250 million disability-adjusted life years lost in 2015.
Raul Coimbra, Allison E Berndtson, Martin Morna, Samuel Debrah   +3 more
doaj   +1 more source

Effect Identification in Comparative Effectiveness Research

eGEMs (Generating Evidence & Methods to improve patient outcomes), 2013
The widespread adoption of electronic medical records means there are now vast data resources available for comparative effectiveness research (CER). In concert with conventional randomized controlled trials, CER holds great promise for advancing our understanding of how different therapeutic treatments yield ...
openaire   +2 more sources

Methods in Comparative Effectiveness Research [PDF]

Journal of Clinical Oncology, 2012
Comparative effectiveness research (CER) seeks to assist consumers, clinicians, purchasers, and policy makers to make informed decisions to improve health care at both the individual and population levels. CER includes evidence generation and evidence synthesis.
openaire   +2 more sources

Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and Identification of Gaps [PDF]

, 2016
BackgroundThe COMET (Core Outcome Measures in Effectiveness Trials) Initiative promotes the development and application of core outcome sets (COS), including relevant studies in an online database.
Clarke, Mike, Gargon, Elizabeth, Gorst, Sarah L, Smith, Valerie, Williamson, Paula R   +4 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source