Results 131 to 140 of about 74,016,645 (279)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Identifying surrogate markers in real-world comparative effectiveness research. [PDF]

Stat Med, 2022
Han L, Wang X, Cai T.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Missing data matter: an empirical evaluation of the impacts of missing EHR data in comparative effectiveness research. [PDF]

J Am Med Inform Assoc, 2023
Zhou Y, Shi J, Stein R, Liu X, Baldassano RN, Forrest CB, Chen Y, Huang J.   +7 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Statistical Framework to Detect and Quantify Operator-Learning Curves in Medical Device Safety Evaluation

Medical Devices: Evidence and Research
Henry C Ssemaganda,1 Sharon E Davis,2 Usha S Govindarajulu,3 Jejo D Koola,4 Jialin Mao,5 Dax Marek Westerman,6 Amy M Perkins,6 Theodore Speroff,7 Craig R Ramsay,8 Art Sedrakyan,5 Lucila Ohno-Machado,9 Michael E Matheny,10,11,* Frederic S Resnic1 ...
Ssemaganda HC, Davis SE, Govindarajulu US, Koola JD, Mao J, Westerman DM, Perkins AM, Speroff T, Ramsay CR, Sedrakyan A, Ohno-Machado L, Matheny ME, Resnic FS   +12 more
doaj  

Draft: Systematic review of cost-effectiveness – Management of Chronic Obstructive Pulmonary Disease in adults

, 2020
The development of evidence-based clinical guidelines requires a holistic approach to evidence identification and appraisal. Accordingly, the National Clinical Effectiveness Committee (NCEC) recommends inclusion of evidence on both the clinical and cost ...
Health Research Board, Collaboration in Ireland for Clinical Effectiveness Reviews (HRB-CICER)   +1 more
core  

Feasibility of Conducting Comparative Effectiveness Research and Validation of a Clinical Disease Activity Score for Chronic Nonbacterial Osteomyelitis. [PDF]

J Rheumatol, 2023
Wu EY, Oliver M, Scheck J, Lapidus S, Akca UK, Yasin S, Stern SM, Insalaco A, Pardeo M, Simonini G, Marrani E, Wang X, Huang B, Kovalick LK, Rosenwasser N, Casselman G, Liau A, Shao Y, Yang C, Mosa DM, Tucker L, Girschick H, Laxer RM, Akikusa JD, Hedrich CM, Onel K, Dedeoglu F, Twilt M, Ferguson PJ, Ozen S, Zhao Y.   +30 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

National Clinical Effectiveness Committee annual report 2013

, 2014
The National Clinical Effectiveness Committee (NCEC) was established as part of the Patient Safety First Initiative in September 2010. The NCECs mission is to provide a framework for national endorsement of clinical guidelines and audit to optimise ...
National Clinical Effectiveness Committee
core