Results 151 to 160 of about 74,016,645 (279)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Ethical Frameworks and Comparative Effectiveness Research

, 2015
Michele Farisco, Carlo Petrini, Farisco, Michele,, Petrini, Carlo,   +3 more
core   +1 more source

An algorithm to predict data completeness in oncology electronic medical records for comparative effectiveness research. [PDF]

Ann Epidemiol, 2022
Merola D, Schneeweiss S, Schrag D, Lii J, Lin KJ.   +4 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparative Effectiveness Research in the Americas on Penetrating Brain Injury: The COMPAS-PBI Study Protocol. [PDF]

Neurosurg Pract
Alvarado-Dyer R, Mansour A, Saleh Velez FG, Bonin-Pinto C, Garwe T, González IZ, Videtta W, Garcia R, Narvaez-Caicedo C, Bonney P, Mijangos J, Vásquez-García S, Flecha J, Rubiano A, Jibaja M, Heredia G, Brasil S, Paiva W, Goldenberg FD, Lazaridis C.   +19 more
europepmc   +1 more source

Journal of Comparative Effectiveness Research welcoming the submission of study design protocols to foster transparency and trust in real-world evidence. [PDF]

J Comp Eff Res, 2023
Walker J, Dormer L, Garner P.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Number Needed to Test in Diagnostic Comparative Effectiveness Research: Implications for Evaluating the Utility and Value of Artificial Intelligence. [PDF]

Korean J Radiol
Park SH, Han K.
europepmc   +1 more source

Characterizing modifications to a comparative effectiveness research study: the OPTIMIZE trial-using the Framework for Reporting Adaptations and Modifications to Evidence-based Interventions (FRAME). [PDF]

Trials, 2023
Fritz JM, Greene T, Brennan GP, Minick K, Lane E, Wegener ST, Skolasky RL.   +6 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source