Results 171 to 180 of about 74,016,645 (279)

Accounting for missing data caused by drug cessation in observational comparative effectiveness research: a simulation study. [PDF]

Ann Rheum Dis, 2022
Mongin D, Lauper K, Finckh A, Frisell T, Courvoisier DS.   +4 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Instrumental variable approaches for estimating time-varying treatment effects in comparative effectiveness research. [PDF]

BMC Med Res Methodol
Tompsett D, Vansteelandt S, Grieve R, Dixon W, Gomes M.   +4 more
europepmc   +1 more source

ISPE-Endorsed Guidance in Using Electronic Health Records for Comparative Effectiveness Research in COVID-19: Opportunities and Trade-Offs. [PDF]

Clin Pharmacol Ther, 2022
Sarri G, Bennett D, Debray T, Deruaz-Luyet A, Soriano Gabarró M, Largent JA, Li X, Liu W, Lund JL, Moga DC, Gokhale M, Rentsch CT, Wen X, Yanover C, Ye Y, Yun H, Zullo AR, Lin KJ.   +17 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Is propensity score matching still a valid design choice for surgical comparative effectiveness research? [PDF]

J Thorac Cardiovasc Surg
Wan F.
europepmc   +1 more source

Comparative effectiveness research in COVID-19 using real-world data: methodological considerations. [PDF]

J Comp Eff Res, 2021
Read SH, Khachatryan A, Chandak A, Casciano R, Hodgkins P, Haubrich R, Mozaffari E.   +6 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Cognitive training, exercise training or combined training? A comparative effectiveness research study on subjective and objective cognitive outcomes in multiple sclerosis. [PDF]

J Neurol
Gyger N, Monschein T, Filser M, Bätge S, Renner A, Roth M, Aktas O, Albrecht P, Hartung HP, Penner IK.   +9 more
europepmc   +1 more source

Experimenting with modifications to consent forms in comparative effectiveness research: understanding the impact of language about financial implications and key information. [PDF]

BMC Med Ethics, 2022
Niyibizi NK, Speight CD, Najarro G, Mitchell AR, Sadan O, Ko YA, Dickert NW.   +6 more
europepmc   +1 more source