Results 131 to 140 of about 823,177 (315)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An Evaluation of Artificial Intelligence (AI) Technologies in Islamic Inheritance Law Knowledge: A Comparison of ChatGPT and Google Gemini

İslam Hukuku Araştırmaları Dergisi
The rapid development of artificial intelligence models has sparked debates about the potential of these technologies to replace human labor across various sectors; in some areas, significant reductions in personnel have already been executed, with ...
Hüseyin Okur
doaj   +1 more source

The evaluation of research in the UK and Japan [PDF]

Most industrial countries have introduced a system of evaluation in the HE sector during the last two decades. Although the experience in each country is different, recent studies show that many countries have faced similar confusion and problems with
Yamazaki, Naoko
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Case-Study-Based Comparative Evaluation of Functional Analysis Paradigms in Aircraft System Design

Applied Sciences
Functional analysis plays a critical role in early-stage aircraft system design by defining system functions that guide downstream architectural development and verification.
Haomin Li, Meng Zhao, Yong Chen, Youbai Xie   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Final Report Comparative Health Services Evaluation Project Navajo Health Authority 1967-1977

, 2014
The Comparative Health Services Evaluation Project (CHSEP) Phase 3 was conducted by the Navajo Health Authority, Division of Health Statistics and Research, for the Navajo Area Indian Health Service (IHS) from July 1976 through June 30, 1977.
Hudson M., Broudy DW., Yellowhair M., May PA., Battese K.   +4 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Evaluations are inherently comparative, but are compared to what?

Journal of Personality and Social Psychology
Understanding how objective quantities are translated into subjective evaluations has long been of interest to social scientists, medical professionals, and policymakers with an interest in how people process and act on quantitative information. The theory of decision by sampling proposes a comparative procedure: Values seem larger or smaller based on ...
Minah H. Jung, Clayton R. Critcher, Leif D. Nelson   +2 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source