Results 71 to 80 of about 657,862 (267)

Comparative Evaluation of Machine-Learning Classifiers for High-Dimensional Gene Expression Data

IEEE Access
High-dimensional gene expression data pose substantial challenges for machine-learning–based diagnostic modelling due to extreme dimensionality, noise, heterogeneous measurement conditions, and limited sample sizes.
Sergii Babichev, Oleg Yarema
doaj   +1 more source

Evodiamine derivatives improve cognitive abilities in APPswe/PS1ΔE9 transgenic mouse models of Alzheimer's disease

Animal Models and Experimental Medicine, 2020
Background Alzheimer's disease (AD) is a complex neurodegenerative disease. Due to the complexity of its molecular pathogenesis and the interaction of the numerous factors involved, the etiology and pathogenesis of AD have not been fully elucidated ...
Shuo Pang, Caixian Sun, Shan Gao, Yajun Yang, Xiandao Pan, Lianfeng Zhang   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

SC Johnson Guardian™ spatial repellent shows 1-year efficacy against wild pyrethroid-resistant Anopheles arabiensis, with a similar blood-feeding inhibition efficacy to Mosquito Shield™ in a Tanzanian experimental hut trial

Frontiers in Malaria
BackgroundSpatial repellents (SRs) that passively emanate airborne concentrations of an active ingredient within a space disrupt mosquito behaviors to reduce human-vector contact.
Johnson Kyeba Swai, Johnson Kyeba Swai, Johnson Kyeba Swai, Watson Samuel Ntabaliba, Emmanuel Mbuba, Emmanuel Mbuba, Emmanuel Mbuba, Hassan Ahamad Ngoyani, Noely Otto Makungwa, Antony Pius Mseka, John Bradley, Madeleine Rose Chura, Thomas Michael Mascari, Sarah Jane Moore, Sarah Jane Moore, Sarah Jane Moore, Sarah Jane Moore   +16 more
doaj   +1 more source

The association between paralytic side and health-related quality of life in facial palsy: a cross-sectional study of the Korea National Health and Nutrition Examination Survey (2008–2012)

Health and Quality of Life Outcomes, 2018
Background Facial palsy is known to have correlations with low level of quality of life. However, little is known about the association between preference based health-related quality of life (HRQoL) and paralytic side of facial palsy. Methods This study
Sina Kim, Hye-Yoon Lee, Nam-Kwen Kim, Tae Han Yook, Eun-Sung Seo, Jong Uk Kim   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Patients’ responses to incidentally discovered silent brain infarcts – a qualitative study

Journal of Patient-Reported Outcomes, 2019
Background Incidentally discovered silent brain infarcts (id-SBIs) are an understudied condition with probable clinical significance, but it is not known how patients respond to or prioritize this condition.
Lester Y. Leung, Paul K. J. Han, Christine Lundquist, Gene Weinstein, David E. Thaler, David M. Kent   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source