Results 51 to 60 of about 15,312,059 (291)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Critical length screening enables 19% efficiency in thick-film organic solar cells

open access: yesNature Communications
The commercialization of organic solar cells (OSCs) requires thick-film active layers, yet current thick-film-compatible acceptor selection based on zero-field mobility is unreliable due to methodological inconsistencies in experimental protocols ...
Yuan Meng   +20 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Subjective image quality comparison between two digital dental radiographic systems and conventional dental film

open access: yesSaudi Dental Journal, 2014
Objectives: Digital radiography has become an integral part of dentistry. Digital radiography does not require film or dark rooms, reduces X-ray doses, and instantly generates images.
Muhammed Ajmal, Mohamed I. Elshinawy
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

INTRASEMIOTIC AND INTRALINGUAL TRANSLATION TECHNOLOGIES: FROM NOVEL TO FILM TEXT

open access: yesВестник Волгоградского государственного университета: Серия 2. Языкознание, 2017
The author studies the problem of transforming the text of a work of fiction during its film adaptation. A fantasy book series by George R.R. Martin, A Song of Ice And Fire, and its HBO adaptation, Game of Thrones series, were chosen as the object of the
Aleksandr S. Besedin
doaj   +1 more source

Common mental disorder symptoms among patients with malaria attending primary care in Ethiopia: a cross-sectional survey. [PDF]

open access: yesPLoS ONE, 2014
BACKGROUND:Common Mental Disorders (CMDs) are frequent among patients attending primary care. In Africa, CMDs are often misdiagnosed as physical illnesses because many of the patients complain of somatic symptoms of mental distress.
Markos Tesfaye   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

QFT Programme & Film Directions 1986 Jan-Feb

open access: yes, 1986
Queen's Film Theatre programme from January to February 1986. A number of film reviews and images are included, as are screening dates and times. Film Directions (Vol. 8, No. 29) is also included.
Queen's Film Theatre; Film Directions
core   +1 more source

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