Results 191 to 200 of about 2,755,876 (359)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Predicting regulons and their cis-regulatory motifs by comparative genomics [PDF]

, 2000
Abigail L. Manson
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

A phylogenetic approach to comparative genomics. [PDF]

Nat Rev Genet
Dewar AE, Belcher LJ, West SA.
europepmc   +1 more source

Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes [PDF]

, 2000
Rachel E. Ellsworth, D. Curtis Jamison, Jeffrey W. Touchman, Stephanie L. Chissoe, Valerie V. Maduro, Gerard G. Bouffard, Nicole Dietrich, Stephen M. Beckstrom‐Sternberg, Leslie M. Iyer, Lauren Weintraub, Marc Cotton, Laura Courtney, Jennifer Edwards, Rachel Maupin, Philip Ozersky, Theresa Rohlfing, P. Wohldmann, Tracie L. Miner, K. Kemp, Jason Kramer, Ian Korf, Kimberlie Pepin, Lucinda Antonacci-Fulton, Robert S. Fulton, Patrick Minx, LaDeana W. Hillier, Richard K. Wilson, R Waterston, Webb Miller, Eric D. Green   +29 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Genetic diversity and comparative genomics across Leishmania (Viannia) species. [PDF]

Commun Biol
Gonzalez-Garcia LN, Rodriguez MP, Parra-Muñoz M, Clavijo AM, Levy L, Ovalle-Bracho C, Colorado C, Camargo C, Quiceno E, Moncada MJ, Muskus C, Urrea DA, Baez-Aguirre F, Restrepo S, Echeverry MC, Duitama J.   +15 more
europepmc   +1 more source

Comparative Genomic Hybridization in Pineal Germ Cell Tumors [PDF]

, 2000
Christian Rickert, Ronald Simon, Markus Bergmann, Barbara Dockhorn‐Dworniczak, Werner Paulus   +4 more
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

PlastidHub: An integrated analysis platform for plastid phylogenomics and comparative genomics. [PDF]

Plant Divers
Zhang NN, Stull GW, Zhang XJ, Fan SJ, Yi TS, Qu XJ.   +5 more
europepmc   +1 more source