Results 131 to 140 of about 3,258,123 (297)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Recommendations from the ASCO Academic Global Oncology Task Force

, 2020
In recognition of the rising incidence and mortality of cancer in low- and middle-resource settings, as well as the increasingly international profile of its membership, ASCO has prioritized efforts to enhance its engagement at a global level.
Bhatt, Ami Siddharth, Close, Julia, Eniu, Alexandru E., Loehrer, Patrick J., Chu, Quyen, Asirwa, Fredrick Chite, Tibbits, Michal, Lopes, Gilberto, Gralow, Julie R., Pyle, Doug, Bourlon, Maria T., Shulman, Lawrence N., Von Roenn, Jamie, Ami Siddharth Bhatt, Jamie Von Roenn, Julia Close, Doug Pyle, Quyen Chu, Gilberto Lopes, Lawrence N. Shulman, Fredrick Chite Asirwa, Julie R. Gralow, Maria T. Bourlon, Michal Tibbits, Patrick J. Loehrer, Alexandru E. Eniu   +25 more
core   +1 more source

A study on the relationship between tumor size, tumor grade and lymph node involvement in canine mammary cancer: Simulation of tumor behavior in human breast cancer

Basic & Clinical Cancer Research, 2021
Background: In the last two decades, canine mammary cancer has played an important role in human breast cancer research. In many cases, there are various similarities between the biological and clinical features of canine breast cancer and female breast ...
Sanaz Rismanchi, Pejman Mortazavi, Samad Muhammadnejad   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

DUAL DECONVOLUTION OF CANINE MAMMARY TUMORS REVEALS ROBUST CD4⁺ T CELL ENRICHMENT VIA EPIC AND CIBERSORTX

Journal of Bioinformatics and Genomics
Canine mammary tumors (CMTs) are an excellent model for human breast cancer because of their spontaneous origin and immunological similarity. This study applied dual immune deconvolution — EPIC and CIBERSORTx — to bulk RNA-seq data (GSE136197) from 48 ...
Herath Mudiyanselage R.
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A comparative analysis of startups applying AI in clinical oncology [PDF]

The rise and exploitation of artificial intelligence (AI) in general and in particular the medical field is fuelled by breakthroughs in deep learning (DL), advances in computing hardware devices, as well as the exponential growth of clinical data used ...
Meça, Alba, Ali, Maaruf
core   +1 more source

Resveratrol and Viscum album anticancer effect in canine mammary tumor cell lines

Brazilian Journal of Veterinary Pathology
Mammary gland tumors are the most common neoplasms in female intact dogs and share some biological and histopathological aspects with those in women with breast cancer, making them a good model in comparative oncology.
Luana Dota Vaz, Patrícia de Faria Lainetti, Antônio Fernando Leis Filho, Giovana Pedro, Carlos Eduardo Fonseca-Alves, Renée Laufer-Amorim   +5 more
doaj   +1 more source