Results 191 to 200 of about 3,258,123 (297)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Naturally Occurring Feline Cancers in Comparative Oncology: Translational Insights from Oral Squamous Cell Carcinoma and Mammary Carcinoma. [PDF]

Cancers (Basel)
Wang Y, Yant JE, Pan X.
europepmc   +1 more source

Moving beyond conventional stratified analysis to assess the treatment effect in a comparative oncology study. [PDF]

J Immunother Cancer, 2021
Sun R, McCaw Z, Tian L, Uno H, Hong F, Kim DH, Wei LJ.   +6 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Comparative Cancer Genetics and Veterinary Therapeutics in Dogs and Cats: A Species-Aware Framework for Comparative Oncology. [PDF]

Life (Basel)
Ahn S, Yun JH.
europepmc   +1 more source

DNA damage response proteins in canine cancer as potential research targets in comparative oncology. [PDF]

Vet Comp Oncol, 2022
Hernández-Suárez B, Gillespie DA, Pawlak A.   +2 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

COX-2 expression in mammary invasive micropapillary carcinoma is associated with prognostic factors and acts as a potential therapeutic target in comparative oncology. [PDF]

Front Vet Sci, 2022
Vieira TC, Oliveira EA, Dos Santos BJ, Souza FR, Veloso ES, Nunes CB, Del Puerto HL, Cassali GD.   +7 more
europepmc   +1 more source

MRI for the Assessment of Histotripsy Ablation in a Canine Osteosarcoma Comparative Oncology Model. [PDF]

Ultrasound Med Biol
Vickers ER, Ruger LN, Coutermarsh-Ott SL, Daniel GB, Allen SP, Ziemlewicz TJ, Soliman SB, Malhotra GB, Maxwell AD, Vlaisavljevich E, Tuohy J.   +10 more
europepmc   +1 more source