Results 51 to 60 of about 3,258,123 (297)

Dissecting the Biological Functions of Various Isoforms of Ferredoxin Reductase for Cell Survival and DNA Damage Response

Cells
The ferredoxin reductase (FDXR) gene is expressed as seven isoforms: 1–6 by alternative splicing and 7 by an alternative promoter according to the Entrez Gene Database.
Ken-ichi Nakajima, Shakur Mohibi, Kyle Hong, Xinbin Chen, Jin Zhang   +4 more
doaj   +1 more source

Vet-OncoNet: Developing a Network of Veterinary Oncology and Reporting a Pioneering Portuguese Experience

Veterinary Sciences, 2022
Vet-OncoNet is a replicable tripartite animal cancer database with the scientific and academic purposes of collecting data and producing evidence-based knowledge for cancer science in general.
Katia Pinello, Isabel Pires, Ana Filipa Castro, Paulo Tiago Carvalho, Andreia Santos, Augusto de Matos, Felisbina Queiroga, João Niza-Ribeiro   +7 more
doaj   +1 more source

Comparative oncology in action: vignettes on immunotherapy development. [PDF]

Vet Oncol
Abstract Immunotherapeutic approaches to cancer treatment have gained significant traction in recent years, due in large part to the success of immune checkpoint inhibitors and T cell-based therapies. Comparative oncology is the study of naturally-occurring cancer in companion (pet) animals, mainly dogs, and is a powerful tool in cancer ...
LeBlanc A, Mazcko CN, Mason NJ, Chambers MR, Brockington DM, Pluhar GE, Naik S.   +6 more
europepmc   +3 more sources

Effects of Lapatinib on HER2-Positive and HER2-Negative Canine Mammary Carcinoma Cells Cultured In Vitro

Pharmaceutics, 2021
HER2 is a prognostic and predictive marker widely used in breast cancer. Lapatinib is a tyrosine kinase inhibitor that works by blocking the phosphorylation of the receptor HER2.
Antonio Fernando Leis-Filho, Patrícia de Faria Lainetti, Priscila Emiko Kobayashi, Carlos Eduardo Fonseca-Alves, Renée Laufer-Amorim   +4 more
doaj   +1 more source

TAp63γ is the primary isoform of TP63 for tumor suppression but not development

Cell Death Discovery
TP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be ...
Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang   +9 more
doaj   +1 more source

Comparative Effectiveness Research in Gynecologic Oncology [PDF]

, 2015
The field of gynecologic oncology is faced with a number of challenges including how to incorporate new drugs and procedures into practice, how to balance therapeutic efficacy and toxicity of treatment, how to individualize therapy to particular patients or groups of patients, and how to contain the rapidly rising costs associated with oncologic care ...
Sonali, Patankar, Ana I, Tergas, Jason D, Wright   +2 more
openaire   +2 more sources

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

eLife
Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi, Yanhong Zhang, Vivian Perng, Mingyi Chen, Jin Zhang, Xinbin Chen   +5 more
doaj   +1 more source

Targeting Mechanotransduction in Osteosarcoma: A Comparative Oncology Perspective. [PDF]

Int J Mol Sci, 2020
Mechanotransduction is the process in which cells can convert extracellular mechanical stimuli into biochemical changes within a cell. While this a normal process for physiological development and function in many organ systems, tumour cells can exploit this process to promote tumour progression.
Luu AK, Viloria-Petit AM.
europepmc   +4 more sources

Comparative mammary oncology: canine model [PDF]

BMC Proceedings, 2013
Mammary tumors are the most frequent neoplastic processes of the female dog and represent a problem of large impact in veterinary medicine. In this context, many efforts are being directed towards adopting criteria towards standardization of the diagnosis, understanding behavior and tumor evolution and evaluating prognostic and predictive factors such ...
openaire   +2 more sources