Clinical Pharmacology &Therapeutics, EarlyView.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
Long-term postmarketing safety of psoriasis treatments on autoimmune disease risk: a 15-year nationwide cohort study in Denmark. [PDF]
Skin Health DisKim S +3 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le +8 more
wiley +1 more source
From Custom to Court: The Evolution of Mediation in European Legal Systems
Conflict Resolution Quarterly, EarlyView.ABSTRACT This article traces how European mediation has repeatedly rebalanced three variables—(1) the source of mediator authority, (2) the degree of institutionalization, and (3) the operative meaning of voluntariness—from antiquity to the present. Using three periods—Proto‐Mediation (c. 500 BCE–c. 1750), Classical Mediation (c.
Viktoriia Hamaiunova
wiley +1 more source
Vitamin D Deficiency Is Associated with Increased Mortality and Seizure Risk After Nontraumatic Subarachnoid Hemorrhage: A Propensity Score-Matched Cohort Study. [PDF]
Brain SciAmasa S +4 more
europepmc +1 more source
Food‐Related Attentional Biases in Restrained Eaters: A Meta‐Analysis
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Dietary restraint may contribute to the development and maintenance of eating disorders (EDs), with food‐related attentional biases (ABs) as a key underlying mechanism. We examined associations between dietary restraint and ABs and explored how several methodological factors (i.e., AB mechanism, mode of AB investigation, response ...
Rio Madan, Cristina Martinelli
wiley +1 more source
Systematic Review of Monoclonal Antibody Therapies in Relapsing Multiple Sclerosis: Comparator-Stratified Analysis of Relapse and Disability Outcomes. [PDF]
Med Sci (Basel)Ciubotaru A +15 more
europepmc +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective This systematic review evaluated the feasibility, efficacy, adherence, and methodological quality of ecological momentary intervention (EMI)–based treatments for individuals with diagnosed eating disorders (EDs) and/or obesity. Method Eight electronic databases were systematically searched from inception to January 2026.
Wenlu Mao +4 more
wiley +1 more source
A Systematic Review and Meta-Analysis of the Association Between Depot Medroxyprogesterone Acetate and Cerebral Meningioma. [PDF]
Cancers (Basel)Reynolds LM, Arend RC, Griffin RL.
europepmc +1 more source
The Efficacy of Fixed-Dose Diclofenac and Orphenadrine for Postoperative Pain Management: A Systematic Review. [PDF]
Medicines (Basel)Christopoulos N, Akinosoglou K.
europepmc +1 more source