Results 71 to 80 of about 134,452 (266)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

An Unbalanced Clock Based Dynamic Comparator: A High-Speed Low-Offset Design Approach for ADC Applications

Advances in Electrical and Electronic Engineering, 2019
Currently, dynamic comparator approach necessitates in high-speed and power efficient analog-to-digital converter applications due to its high latching speed and ultra-low power consumption. In this paper, a~novel dynamic comparator is proposed to reduce
Vikrant Varshney, Rajendra Kumar Nagaria
doaj   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Developing, Piloting and Evaluating a Patient Support Portal for Men With Prostate Cancer in Victoria: An Action Research Study

Health Expectations
Introduction Men with prostate cancer (PCa) and their support providers face challenges in accessing high‐quality, impartial information tailored to their specific needs to enhance their overall care and decision‐making.
Benjamin Shemesh, Jacinta L. Opie, Rodney L. Dunn, Garth Mclaughlin, Vivek Argawal, Amanda Pomery, Chris Mac Manus, Colin O'Brien, Katrina Lewis, Max Shub, Paula Wilton, Prassannah Satasivam, Melanie Evans, Jeremy Millar, Sue M. Evans   +14 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

A Review on Fundamentals of Noise-Shaping SAR ADCs and Design Considerations

Chips
A general overview of Noise-Shaping Successive Approximation Register (SAR) analog-to-digital converters is provided, encompassing the fundamentals, operational principles, and key architectures of Noise-Shaping SAR (NS SAR).
Victor H. Arzate-Palma, David G. Rivera-Orozco, Gerardo Molina Salgado, Federico Sandoval-Ibarra   +3 more
doaj   +1 more source

A Low-Power High-Speed Dynamic Comparator With a Transconductance-Enhanced Latching Stage

IEEE Access, 2019
Low-power, high-speed dynamic comparators are highly desirable in the design of high-speed analog-to-digital converters (ADC) and digital I/O circuits. Most dynamic comparators use a pair of cross-coupled inverters as the latching stage, which provides ...
Yao Wang, Mengmeng Yao, Benqing Guo, Zhaolei Wu, Wenbing Fan, Juin Jei Liou   +5 more
doaj   +1 more source

Comparing Comparatives

Leviathan: Interdisciplinary Journal in English
This article explores the acceptability of constructions with double comparative elements in Danish and English. First, a brief introduction to theoretical assumptions for adjective phrases and degree phrases is given. After this, the methodology and challenges of setting up an empirical study are laid out.
openaire   +1 more source