Results 141 to 150 of about 1,468,398 (261)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on fault diagnosis of substation grounding grid based on graph neural network and multi source information fusion. [PDF]

PLoS One
Pu X, Ding H, Zhong L, Chen X.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Practice and Effectiveness Analysis of Multimodal Integrated Teaching Methods in Neurosurgery Clinical Teaching. [PDF]

Adv Med Educ Pract
Xia D, Hu Z, Yuan J, Wu D, Lai N, Jin Y.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Correction: Two distinct healthcare utilisation trajectories prior to a COPD diagnosis in a multi-ethnic asian population: a comparison of transient and chronic users. [PDF]

BMJ Open Respir Res
europepmc   +1 more source

The Oncology Care Model and Initiation of Systemic Therapy for Cancer. [PDF]

JAMA Intern Med
Keating NL, Lam MB, Landrum MB, McWilliams JM, Wright AA, Brooks GA, Zubizarreta JR, Buzzee B, Landon BE.   +8 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Autonomous Distributed Diagnosis Method Comparison to On-line Distributed Diagnosis Method

Transactions of the Japanese Society for Artificial Intelligence, 2006
Hattori, Kiyohiko, Takadama, Keiki, Murata, Satoshi, Furuya, Hiroshi, Ueno, Hiroshi, Inaba, Noriyasu, Oda, Mitsushige   +6 more
openaire   +2 more sources

A two-stage workflow for vitiligo diagnosis: clinical characteristic classification and large language model (LLM)-based report generation. [PDF]

Front Immunol
He K, Xu T, Feng Y, Lu Y, Wang X, Jiang L, Guo S, He Y, Dai W, Zhang W, Zhang J, Lu H, Huang D, Li S.   +13 more
europepmc   +1 more source