Results 251 to 260 of about 6,300,735 (285)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
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Results of an international comparison of 57Co
Applied Radiation and Isotopes, 2010As part of a Cooperative Research Project (CRP) aimed at improving the state of radioactivity measurement in nuclear medicine, the International Atomic Energy Agency (IAEA) organized a comparison of (57)Co solutions among the participants of the project.
B E, Zimmerman, S, Palm
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2013
In this chapter the overall results of this work and the comparison with the latest state-of-the-art approaches are presented. Before moving to the actual comparison, a description of the experimental setup is presented discussing the fairness of comparison in relation to the related works.
Bruno Zatt +3 more
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In this chapter the overall results of this work and the comparison with the latest state-of-the-art approaches are presented. Before moving to the actual comparison, a description of the experimental setup is presented discussing the fairness of comparison in relation to the related works.
Bruno Zatt +3 more
openaire +1 more source
New Results in Minimum-Comparison Sorting
Algorithmica, 2004zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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2018
In this section, the results of CFD simulations and the corrected experimental results are compared, and the final conclusions of the investigation are derived. In addition, offered are recommendations for future research, which evolved from the performed experiments and simulations.
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In this section, the results of CFD simulations and the corrected experimental results are compared, and the final conclusions of the investigation are derived. In addition, offered are recommendations for future research, which evolved from the performed experiments and simulations.
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1995
In this appendix we briefly compare the results in this book with other results, such as wavelets, JPEG, and Iterated Systems, Inc. software. Some of these comparisons appear also in [29]. The results should be taken with a grain, or more aptly a large mountain, of salt for the reasons listed below.
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In this appendix we briefly compare the results in this book with other results, such as wavelets, JPEG, and Iterated Systems, Inc. software. Some of these comparisons appear also in [29]. The results should be taken with a grain, or more aptly a large mountain, of salt for the reasons listed below.
openaire +1 more source