Results 161 to 170 of about 3,221,559 (262)

Comparative Effects of Training Modalities on Countermovement Jump Performance in Soccer Players: A Systematic Review and Network Meta-Analysis. [PDF]

J Sports Sci Med
Dong X, Li T, Xing W, Chen Z.
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

The number needed to treat and relevant between-trial comparisons of competing interventions

, 2018
Jeroen P Jansen,1 Javaria Mona Khalid,2 Michael D Smyth,3 Haridarshan Patel4 1Evidence Synthesis and Decision Modeling, Precision Xtract, Oakland, CA, USA; 2Evidence and Value Generation, Takeda International – UK Branch, London, UK; 3Global ...
Smyth MD, Khalid JM, Jansen JP, Patel H
core  

Comparative Efficacy of Bone Defect Filler Strategies Following Lesion Debridement for Osteonecrosis of the Femoral Head: A Systematic Review and Network Meta-Analysis. [PDF]

Orthop Surg
Miao Z, Pei Z, Wang B, Hou Z, Jia J, Zhao J, Dai J, Sun X, Ma X.   +8 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity. [PDF]

Nat Commun
Eksi B, Finke D, Michel S, Brauer J, Heckmann MB, Valadan M, Schanze LM, Sunder V, Steimel K, Burhenne J, Seeger T, Katus HA, Frey N, Backs J, Lehmann LH.   +14 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

International Comparisons and Transfer of Labour Market Institutions [PDF]

International comparisons of labour market institutions and their transfer across boundaries have gained in importance. The paper deals with the question of the best way to proceed in making such comparisons.
Wolfgang Ochel
core  

Fragile preferences: A deep dive into order effects in large language models. [PDF]

PNAS Nexus
Yin H, Vardi S, Choudhary V.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source