Results 171 to 180 of about 2,883,381 (313)

Comparisons are odious

open access: yesPerspectives in Clinical Research, 2014
openaire   +3 more sources

Risk Comparisons [PDF]

open access: yesAmerican Journal of Ophthalmology, 2009
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

International Comparisons of Labour Market and Skills Performance

open access: yes, 2005
International Comparisons of Labour Market and Skills Performance - key findings: * In terms of economic performance, Gross Domestic Product (GDP) per person in Scotland in 2001 was 80 per cent of the benchmark group average, and much of this was ...
Sutherland, V.   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

International Comparisons and Transfer of Labour Market Institutions [PDF]

open access: yes
International comparisons of labour market institutions and their transfer across boundaries have gained in importance. The paper deals with the question of the best way to proceed in making such comparisons.
Wolfgang Ochel
core  

Between Rigor and Relevance: Why the EU HTA Guidelines on Indirect Comparisons Miss the Mark. [PDF]

open access: yesJ Mark Access Health Policy
Aballéa S   +12 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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