Results 101 to 110 of about 665,350 (278)

Aging as a Loss of Goal‐Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation

open access: yesAdvanced Science, EarlyView.
The paper proposes that the root cause of aging is the loss of anatomical goal‐directedness after development. Using evolutionary neural cellular automata simulations, the authors show that after the organism has reached its developmental homeostatic setpoint (the adult morphology), the absence of target state to pursue leads to a drifting anatomical ...
Léo Pio‐Lopez   +2 more
wiley   +1 more source

Influence of the Upstream Channel of a Ship Lift on the Hydrodynamic Performance of a Fleet Entry Chamber and Design of Traction Scheme

open access: yesJournal of Marine Science and Engineering
This study investigates the hydrodynamic performance of ships entering a ship lift compartment that is under the influence of upstream channel geometry and proposes a mechanical traction scheme to enhance operational safety and efficiency.
Haichao Chang   +6 more
doaj   +1 more source

Model‐based evaluation of the interaction between ritonavir‐boosted atazanavir and rifampicin in Ugandan adults with HIV

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Concomitant treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug‐drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir‐boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC).
Allan Kengo   +10 more
wiley   +1 more source

Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9‐tetrahydrocannabinol in older patients with poor appetite

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Cannabis‐based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of cannabinoids have been performed in healthy adults, this study aimed to investigate the population pharmacokinetics of Δ9 ...
Ida Klitzing Storgaard   +12 more
wiley   +1 more source

Vibration Characteristic Research of 100 m New Polar Exploration Cruise Based on Finite Element Modeling

open access: yesJournal of Marine Science and Engineering
Luxury cruise ships are high-end passenger ships with facilities on board for the leisure and entertainment of passengers, so the comfort of luxury cruise ships is a matter of great concern.
Guohe Jiang   +4 more
doaj   +1 more source

Homogenized modeling for vascularized poroelastic materials [PDF]

open access: yes, 2017
A new mathematical model for the macroscopic behavior of a material composed of a poroelastic solid embedding a Newtonian fluid network phase (also referred to as vascularized poroelastic material), with fluid transport between them, is derived via ...
Merodio, José, Penta, Raimondo
core   +1 more source

Absolute bioavailability and intravenous pharmacokinetics of N‐acetyl‐D‐mannosamine in humans

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims N‐acetyl‐D‐mannosamine monohydrate (ManNAc) is a naturally occurring monosaccharide that has attracted considerable attention for its potential in treating GNE myopathy, a rare autosomal recessive muscle disorder. Despite its promise as an oral treatment, the absolute bioavailability of oral ManNAc has not been determined and there has been no ...
Tahlia R. Meola   +6 more
wiley   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding   +24 more
wiley   +1 more source

Alien species established in the Bay of Biscay suggest significant contribution of both fouling and dry ship compartments [PDF]

open access: gold, 2023
Deva Menéndez-Teleña   +6 more
openalex   +1 more source

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