Results 101 to 110 of about 79,564 (250)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Self-organization in bipolar disorder: Compartmentalization and self-complexity

The present study investigated compartmentalization and self-complexity of self-structure in people with a history of bipolar disorder. Remitted bipolar, recovered depressed and healthy control participants described aspects of themselves using ...
Barton SB, Taylor JL, Morley S
core   +4 more sources

Supplementary Figure from CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity

, 2022
Supplementary Figure from CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell ...
Jianfeng Chen (15135375), Qi Wang (15135384), Xinyue Lv (15135366), Weiguo Hu (15135396), Luying Li (15135360), Xiaochao Wang (15135381), Peipei Ding (15135363), Wei Zhang (15135387), Suhong Xie (15135369), Yanqing Xu (15135390), Renquan Lu (15135393), Ling Li (15135372), Danlei Zhou (15135378)   +12 more
core   +1 more source

Peroxisomes: A New Hub for Metabolic Engineering in Yeast

Frontiers in Bioengineering and Biotechnology, 2021
Natalja Kulagina, Sébastien Besseau, Nicolas Papon, Vincent Courdavault   +3 more
doaj   +1 more source

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Compartmentalization and Aggregation of Biomolecular Condensates in Crowded Hydrogels for Enhanced Nucleic Acid Diagnosis

Advanced Science
Membrane‐less compartments, such as biomolecular condensates, play a crucial role in cellular organization by enhancing enzymatic reaction efficiency through compartmentalization and crowding.
Fangbin Xiao, Tao Yang, Mei Fang, Xingyu Lin   +3 more
doaj   +1 more source