A proof of concept for a one-pot process merging a heterocycle formation by a classical chemical approach at basic conditions with a biocatalytic reduction, running at neutral pH conditions, is reported.
Nadine Zumbrägel, Harald Gröger
doaj +1 more source
Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha +4 more
core
Compartmentalization of incompatible reagents within Pickering emulsion droplets for one-pot cascade reactions [PDF]
It is a dream that future synthetic chemistry can mimic living systems to process multistep cascade reactions in a one-pot fashion. One of the key challenges is the mutual destruction of incompatible or opposing reagents, for example, acid and base ...
Binks, Bernard P. +4 more
core +2 more sources
Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement
In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions and rearrangement of membrane structures initiated upon ...
Dominik eFilipp +2 more
doaj +1 more source
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner +4 more
doaj +1 more source
Stable isotope tracing reveals compartmentalized nitrogen assimilation in scleractinian corals
Corals form symbiotic relationships with dinoflagellate algae of the family Symbiodiniaceae, bacteria, and other microbes. Central to that relationship is the regulation of nutrition flux between the animal host and the photosynthetic Symbiodiniaceae ...
Eric N. Chiles +8 more
doaj +1 more source
Identifying compartments in ecological networks based on energy channels
It has been confirmed in many food webs that the interactions between species are divided into “compartments,” that is, subgroups of highly interacting taxa with few weak interactions between the subgroups.
Lei Zhao +3 more
doaj +1 more source
This review illuminates key findings in our understanding of grapevine xylem resistance to fungal vascular wilt diseases. Grapevine (Vitis spp.) vascular diseases such as esca, botryosphaeria dieback, and eutypa dieback, are caused by a set of ...
Jerome ePouzoulet +3 more
doaj +1 more source
Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution
Speciation, an evolutionary process by which new species form, is ultimately responsible for the incredible biodiversity that we observe on Earth every day.
Tony Z. Jia +2 more
doaj +1 more source
Beyond Good and Evil: Formalizing the Security Guarantees of Compartmentalizing Compilation
Compartmentalization is good security-engineering practice. By breaking a large software system into mutually distrustful components that run with minimal privileges, restricting their interactions to conform to well-defined interfaces, we can limit the ...
de Amorim, Arthur Azevedo +4 more
core +3 more sources

