Results 61 to 70 of about 10,794 (263)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Phenylpropanoid Case – It Is Transport That Matters
Frontiers in Plant Science, 2018 Phenylpropanoids fulfill numerous physiological functions, essential for plant growth and development, as well as plant–environment interactions. Over the last few decades, many studies have shown that exquisite regulatory mechanisms at multiple levels ...
Wanda Biała +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Understanding Compartmentation Failure for High-Rise Timber Buildings
FireThe traditional concept of compartmentation guaranteed by fire resistance is mainly concerned with the problem of destructive internal spread potential. External convective spread potential pertains to the loss of compartmentation associated with windows
Agustín H. Majdalani +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Evidence for a compartmentation of brain microsomal diacylglycerol
Journal of Lipid Research, 1982 Phosphatidylcholine synthesis from CDP-[methyl-14C]choline and membrane-bound diacyl-[U-14C]-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes.
L Binaglia +3 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
COMPARTMENTATION OF THE MITOCHONDRION [PDF]
Proceedings of the National Academy of Sciences, 1965 G, BRIERLEY, D E, GREEN
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Revista Águas Subterrâneas, 2018 The objective of this work was to evaluate the compartmentation of the Guarani Aquifer System (GAS) in the Serra Geral escarpment in the northeast of the RS.
Alex Bortolon de Matos +2 more
doaj +1 more source