Results 41 to 50 of about 13,615 (306)
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes
, 2008 ATP generation by both glycolysis and glycerol catabolism is autocatalytic, because the first kinases of these pathways are fuelled by ATP produced downstream.
Westerhoff, Hans V. +25 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Compartmentalized Neuronal Cultures [PDF]
, 2013 The culturing of neurons results in formation of the layer of neurons with random extensive overlapping outgrowth. To understand specific roles of somas, axons, and dendrites in complex function of neurons and to identify molecular mechanisms of biological processes in these cellular compartments various methods were developed.
Armine, Darbinyan +4 more
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Revista de la Facultad de Ciencias Agrarias, 2020 A correct selection of salt-tolerant plants should consider the relative effects of the various existing tolerance mechanisms. When toxic ions, like Na+, reach the leaves, they affect the photosynthetic apparatus, reducing plant growth and ...
Hernán F. Vila +4 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FireThis article focuses on the fire safety risks associated with conventional glass–aluminum façades—with a particular focus on stick and unitized curtain walling systems—providing an overview of possible fire spread mechanisms, considering the role of the ...
Arritokieta Eizaguirre-Iribar +3 more
doaj +1 more source
Horticulture Research, 2019 In developing apple fruit, metabolic compartmentation is poorly understood due to the lack of experimental data. Distinguishing subcellular compartments in fruit using non-aqueous fractionation has been technically difficult due to the excess amount of ...
Wasiye F. Beshir +6 more
doaj +1 more source
Alterations of cAMP-dependent signaling in dystrophic skeletal muscle
Frontiers in Physiology, 2013 Autonomic regulation processes in striated muscles are largely mediated by cAMP/PKA-signaling. In order to achieve specificity of signaling its spatial-temporal compartmentation plays a critical role. We discuss here how specificity of cAMP/PKA-signaling
Rüdiger eRudolf +6 more
doaj +1 more source