Results 111 to 120 of about 165,938,772 (216)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Construction of the REACHES climate database based on historical documents of China. [PDF]

Sci Data, 2018
Wang PK, Lin KE, Liao YC, Liao HM, Lin YS, Hsu CT, Hsu SM, Wan CW, Lee SY, Fan IC, Tan PH, Ting TT.   +11 more
europepmc   +1 more source

The polymorphism and tradition of funerary practices of medieval Turks in light of new findings from Tuva Republic. [PDF]

PLoS One, 2022
Chan A, Sadykov T, Blochin J, Hajdas I, Caspari G.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Chronicles of Oklahoma

, 1943
Article consists of articles connected to the history of the state of Oklahoma. The first article explains the existence of ghost towns within the Indian Territory. The second article chronicles the genealogy and career of George Samuel Ramsey. The third
Townsend, A. C., Williams, Robert L., Foreman, Carolyn Thomas, 1872-1967   +2 more
core  

Brief history of ophidiology and ophidism in Colombia. [PDF]

Trans R Soc Trop Med Hyg
Cañas CA, Castaño-Valencia S, Castro-Herrera F.   +2 more
europepmc   +1 more source

The role played by government communication on the level of public fear in social media: An investigation into the Covid-19 crisis in Italy. [PDF]

Gov Inf Q, 2023
Lerouge R, Lema MD, Arnaboldi M.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Trends of infectious diseases, epidemic patterns, and the association with meteorological events: 2500 years of evidence from an observational study. [PDF]

J Glob Health
Liu Q, Qin C, Zhang S, Liu J.
europepmc   +1 more source

Kaddish During COVID: Mourning Rituals During a Pandemic. [PDF]

Contemp Jew, 2021
Cooper L.
europepmc   +1 more source