Results 111 to 120 of about 258 (197)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Contextualizing contemporary seasonality variations in East Asian tropical cyclone landfalls with a multi-century historical baseline. [PDF]

NPJ Clim Atmos Sci
Zhang G, Lin KE, Fu D, Knutson T, Franke J, Tseng WL.   +5 more
europepmc   +1 more source

Underground and Over the Sea: More Community Prophylactics in Europe, 1100-1600. [PDF]

J Hist Med Allied Sci, 2021
Geltner G, Weeda C.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Temporal and Spatial Effects of Extreme Drought Events on Human Epidemics over Ancient China in 1784-1787 CE. [PDF]

Environ Health
Hang X, Sun Z, He J, Xin J, Zhang S, Zhao Y, Tan Z, Han L, Hao Y.   +8 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Рукописи исторического сочинения Jāmiʿ at-Tawārīkh «Сборник летописей» Кадыр Али бека [Manuscripts of Qādir ʿAli beg’s historical work Jāmiʿ at-Tawārīkh ‘Compendium of Chronicles] [PDF]

, 2022
openaire   +1 more source

Reconstruction of the Temperature Index Series of China in 1368-1911 based on REACHES database. [PDF]

Sci Data
Wang PK, Lin KE, Lin YS, Lin HJ, Pai PL, Tseng WL, Huang HC, Lee CR.   +7 more
europepmc   +1 more source

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review. [PDF]

Front Pharmacol, 2022
Quan XX, Huang YY, Chen L, Yuan JQ.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source