Results 131 to 140 of about 165,938,772 (216)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Contextualizing contemporary seasonality variations in East Asian tropical cyclone landfalls with a multi-century historical baseline. [PDF]

NPJ Clim Atmos Sci
Zhang G, Lin KE, Fu D, Knutson T, Franke J, Tseng WL.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Рукописи исторического сочинения Jāmiʿ at-Tawārīkh «Сборник летописей» Кадыр Али бека [Manuscripts of Qādir ʿAli beg’s historical work Jāmiʿ at-Tawārīkh ‘Compendium of Chronicles] [PDF]

, 2022
openaire   +1 more source

Temporal and Spatial Effects of Extreme Drought Events on Human Epidemics over Ancient China in 1784-1787 CE. [PDF]

Environ Health
Hang X, Sun Z, He J, Xin J, Zhang S, Zhao Y, Tan Z, Han L, Hao Y.   +8 more
europepmc   +1 more source

Genomic insights into longan evolution from a chromosome-level genome assembly and population genomics of longan accessions. [PDF]

Hortic Res, 2022
Wang J, Li J, Li Z, Liu B, Zhang L, Guo D, Huang S, Qian W, Guo L.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A systematic, updated review of Xuezhikang, a domestically developed lipid-lowering drug, in the application of cardiovascular diseases. [PDF]

Acta Pharm Sin B
Yang C, Wu Y, Qian J, Li JJ.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Reconstruction of the Temperature Index Series of China in 1368-1911 based on REACHES database. [PDF]

Sci Data
Wang PK, Lin KE, Lin YS, Lin HJ, Pai PL, Tseng WL, Huang HC, Lee CR.   +7 more
europepmc   +1 more source