Results 211 to 220 of about 5,233,254 (268)

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

open access: yesAdvanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun   +7 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

open access: yesAdvanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang   +4 more
wiley   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu   +10 more
wiley   +1 more source

Resource allocation, hyperphagia and compensatory growth [PDF]

open access: yesBulletin of Mathematical Biology, 2004
Organisms often shown enhanced growth during recovery from starvation, and can even overtake continuously fed conspecifics (overcompensation). In an earlier paper (Ecology 84, 2777-2787), we studied the relative role played by hyperphagia and resource allocation in producing overcompensation in juvenile (non-reproductive) animals.
Gurney, William S. C., Nisbet, Roger M.
core   +8 more sources
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Modelling Compensatory Growth

Functional Ecology, 1994
1. We formulate a simple, physiologically based model to investigate the phenomenon of compensatory growth. 2. The model is based upon two key assumptions. First, that an individual partitions net assimilate between two tissue types: those which can and those which cannot be remobilized once laid down.
Broekhuisen, N.   +3 more
openaire   +2 more sources

Mechanisms of reduced and compensatory growth

Domestic Animal Endocrinology, 2000
Growth is an integrated process, resulting from the response of cells dependent on the endocrine status and nutrient availability. During feed restriction, the production and secretion of growth hormone (GH) by the pituitary gland are enhanced, but the number of GH receptors decreases.
Hornick, Jean-Luc   +4 more
openaire   +2 more sources

Kinetics of Compensatory Growth

The Quarterly Review of Biology, 1965
Growth in tissues and organs can be stimulated by either partial ablation or increased demands for physiological activity. Both causes appear to operate via identical pathways whereby the mounting requirements for extra functional output stimulate DNA replication and concomitantly promote specific protein synthesis.
openaire   +2 more sources

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