Results 151 to 160 of about 131,362 (199)

Developing context-specific competencies for epidemic and pandemic preparedness in the MENA region: a training needs assessment and Delphi approach. [PDF]

Front Public Health
Ibrahim S, Alaeddine R, Chamseddine Z, Zaouk N, Awad Z, Abdul-Sater Z, Saleh S.   +6 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Establishing career competencies for the fourth industrial revolution: a qualitative study of expert perspectives in South Africa. [PDF]

Front Psychol
Mtshali S, Dhanpat N.
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Educational interventions for training oncology residents in palliative medicine: a rapid review of the available evidence to inform training standards in cancer care. [PDF]

Support Care Cancer
Cheng J, Centeno I, Laird BJA, Lõhmus M, Chlebopaševienė G, Foss L, Kaasa S, Centeno C.   +7 more
europepmc   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Interpreting the New Competency-Based Medical Education Curriculum of Biochemistry for Undergraduate Medical Students in India: A Narrative Review. [PDF]

Cureus
Acharya NN, Biswas K, Gavel P.
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Competències locals viàries. Especial referència a les competències locals viàries a Catalunya

Revista Catalana de Dret Públic, 1996
Concepción Martínez-Carrasco Pignatelli
doaj  

Correction: Global learning opportunities within social innovation in health (GLOWS): A modified Delphi process to identify and pilot core competencies for learning. [PDF]

PLoS One
Wallace E, Tao Y, Aribodor OB, Zhu Z, Borbón A, Halpaap B, Chakhame BM, Jacob EC, Ahmed F, Francis JM, Septiawan KG, Mawuli K, Mutisya L, Ekasari MP, Azugo NO, Fourie T, Ruiz AS, Alger J, Mier AR, Tang W, Aidoo-Frimpong G, Nanono J, Montealto JJA, Ezezika O, Kåks P, Shan W, Mier-Alpano JD, Marley G, Chen E, Tucker JD.   +29 more
europepmc   +1 more source