Results 51 to 60 of about 61,136 (258)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Quadern de pràctiques del Tutor/a de Centre (Curs 2010-2011). El pràcticum: espai per la transferència de competències i el desenvolupament professional. [PDF]

, 2012
Aquest quadern de pràctiques vol ser una eina de consulta i suport per als professionals tutors i tutores dels centres col·laboradors que són una de les peces clau per facilitar la transferència de les competències de l'estudiantat d'educació social ...
Caramés Boada, Marta, Costa Cámara, Sandra, Forés i Miravalles, Anna, Freixa Niella, Montserrat, Fuentes-Peláez, Núria, Novella Cámara, Ana M. (Ana María), Pérez Escoda, Núria   +6 more
core  

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

A Delphi study on health literacy competencies for health professionals

BMC Medical Education
Background Health professionals play a key role in promoting health literacy, as they continue to be one of the main points of contact and most trusted source of information for healthcare users on questions and concerns regarding health and disease.
Anna-Sophia Beese, Rebecca Jaks, Elena Alder, Saskia Maria De Gani   +3 more
doaj   +1 more source

Employer insights into key competencies for human resource management graduates: a Q-methodology study

Cogent Education
This study aims to investigate the subjective views of HRM professionals regarding the competencies essential for HRM graduates, focusing on identifying distinct competency preference groups, understanding their perceived importance and prioritization of
Eszter Bogdány, Gabriella Cserháti, Tibor Csizmadia   +2 more
doaj   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Twenty-first-century competencies and capabilities for financial accounting students

South African Journal of Economic and Management Sciences
Background: The financial accounting profession faces several challenges in the 21st century. Research is needed to prepare financial accountants for these challenges. Aim: This study aimed to determine which 21st-century competencies were essential for
Elette van den Berg, Sebastiaan Rothmann
doaj   +1 more source

Llegir i escriure críticament en el context d'assignatures impartides en anglès : el cas de la titulació de mestre especialitat llengua estrangera [PDF]

, 2007
L'ensenyament d'assignatures en terceres llengües és una prioritat de la Comunitat Europea, del DURSI, del Departament d'Educació de la Generalitat de Catalunya, de la UAB, de la Facultat de Ciències de l'Educació d'aquesta mateixa universitat, i també ...
Codó, Eva, Couso, Digna, Espinet, Mariona, Feixas, Mònica, Masats, Dolors   +4 more
core  

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

Advanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen, Xiaoni Gao, Shuai Lu, Yi Zhang, Xing Zheng, Matthaios Santamouris   +5 more
wiley   +1 more source

Perceptions and Level of ICT Competencies

Pakistan Journal of Information Management & Libraries, 2016
This paper intends to explore the level of ICT competencies, and the training needs for updating these competencies among library professionals in Khyber Pakhtunkhwa, Pakistan.
Shamshad Ahmed, Atta-Ur- Rehman
doaj