Results 71 to 80 of about 1,466,248 (386)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Current landscape of research ethics consultation services: National survey results

Journal of Clinical and Translational Science, 2023
Introduction: The goal of a research ethics consultation service (RECS) is to assist relevant parties in navigating the ethical issues they encounter in conduct of research. The goal of this survey was to describe the current landscape of research ethics
Holly A. Taylor, Kathryn M. Porter, Connor Sullivan, Jennifer B. McCormick   +3 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Revolutionizing the Public Health Workforce—A Policy Brief in Retrospect of the World Congress on Public Health Rome 2020

Public Health Reviews, 2023
Background: The COVID-19 pandemic dramatically illustrates the consequences of inadequate prioritization of the Public Health Workforce (PHW). This Policy Brief introduces a Call for Action following the plenary session entitled “Revolutionising the ...
Barbara Maria Bürkin, Barbara Maria Bürkin, Pete Milos Venticich, Philip Baba Adongo, Naomar De Almeida-Filho, Laura Magaña, John Middleton, Luis Eugenio Souza, Luis Eugenio Souza, Katarzyna Czabanowska, Katarzyna Czabanowska   +10 more
doaj   +1 more source

Ranking workplace competencies: Student and graduate perceptions [PDF]

, 2002
Students and graduates from a variety of business studies programs at a New Zealand tertiary institution completed a questionnaire in which they ranked the relative importance of a list of 24 competencies for graduates entering the workforce using a 7 ...
Burchell, Noel, Hodges, David Leslie, Lay, Mark C., Rainsbury, Elizabeth   +3 more
core  

Exploring assessment of medical students\u27 competencies in pain medicine - A review [PDF]

, 2019
Introduction: Considering the continuing high prevalence and public health burden of pain, it is critical that medical students are equipped with competencies in the field of pain medicine. Robust assessment of student expertise is integral for effective
Adillon, Adwan, Al-Rukban, Ali, Ali, Ameringer, Anderson, Antman, Argyra, Arwood, Banja, Biggs, Breivik, Briggs, Briggs, Carr, Carraccio, Case, Cohen, Corrigan, Dominick, Downing, Driessen, Eijsvogels, Emke, Epstein, Epstein, Erickson, Fabbian, Ferris, Fete, Finnerup, Fishman, Fishman, Frank, Frenk, Gatchel, Gehlhar, Ger, Gerbershagen, Gordon, Green, Gruppen, Hanna, Haq, Harden, Harendza, Harlen, Hirsh, Hoy, Hunter, Hunter, Kaki, Kennedy, Khan, Lasch, Lee, Leila, Lockyer, Loeser, Manalo, Manchikanti, Merrill, Mezei, Miller, Morley-Forster, Morris, Murinson, Nabishah, Niemi-Murola, Nimmaanrat, Oudkerk Pool, Paneduro, Pilowsky, Plymale, Portenoy, Puljak, Pöyhiä, Rainville, Reeves, Salam, Schopflocher, Schreiner, Schuwirth, Shipton, Shipton, Siddall, Silva, Sloan, Sloan, Sloan, Stevens, Strohbuecker, Symonds, Tauben, Tellier, Terry, Thomson, Turner, Twigg, van den Beuken-van Everdingen, van der Vleuten, Wass, Watt-Watson, Watt-Watson, Weiner, Weinstein, Weissman, Wijnen-Meijer, Yanni   +109 more
core   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Competencies of the UK nursing and midwifery workforce to mainstream genomics in the National Health Service: the ongoing gap between perceived importance and confidence in genomics

Frontiers in Genetics, 2023
The United Kingdom is recognised worldwide as a leader in genomics. The use of genomic technologies in the National Health Service (NHS) is expected to deliver faster and more accurate diagnoses, supporting personalized treatments to improve patient ...
Catherine Carpenter-Clawson, Melanie Watson, Alison Pope, Kathleen Lynch, Tracie Miles, Dany Bell, Maureen Talbot, Aniko Varadi   +7 more
doaj   +1 more source

Didactic Strategies to Promote Competencies in Sustainability

Sustainability, 2019
Higher education is a principal agent for addressing the sustainable development goals proposed by the 2030 Agenda, because of its key mission of knowledge generation, teaching and social innovation for sustainability.
G. Tejedor, J. Segalás, Á. Barrón, M. Fernández-Morilla, M. Fuertes, J. Ruiz-Morales, Ibon Gutiérrez, E. García-González, Pilar Aramburuzabala, Àngels Hernández   +9 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source