Results 221 to 230 of about 333,512 (299)

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Systems Thinking: Identifying Leverage Points for Achieving a Continuum of Competency-Based Health Professions Education. [PDF]

Perspect Med Educ
Hauer KE, Damodaran AK, Frank JR, Huwendiek S, Marty AP, Richardson D, Schumacher DJ, Tanaka P, Turner TL, Rhoney DH, International Competency-Based Health Professions Education Collaborators.   +10 more
europepmc   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

A Workforce-Informed Competency Framework Defines 30 Core Abilities of Veterinary Diagnostic Imaging Specialists. [PDF]

Vet Radiol Ultrasound
Noyes JA, Brisson J, Buckley GJ, Hammond L, Manzi T, Pollard RE, Sage J, Waller KR, Welch P.   +8 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Clinical Nurse Specialists' Perceptions of Competency and Self-Efficacy in Evidence-Based Practice and Implementation Science. [PDF]

Worldviews Evid Based Nurs
Shay A, McNett M, Tucker S, Fulton JS.
europepmc   +1 more source

The Educational Alliance: Essential to Implement Competency-Based Health Professions Education. [PDF]

Perspect Med Educ
Hauer KE, Goldhamer MEJ, Amiel J, Richardson D, Schwartz A, Marty AP, Molgaard L, Pinilla S, Breckwoldt J, As members of the International Competency-Based Health Professions Educators Collaborative.   +9 more
europepmc   +1 more source