Results 61 to 70 of about 784,195 (317)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

What influences the actual use of competency management by the first-line manager? [PDF]

, 2010
Existing research shows that the first-line manager plays an important role in actually using HRM in general and competency management in particular. Existing theory and research in both domains point at a gap in understanding the mechanisms ‘how’ the ...
Audenaert, Mieke, Buyens, Dirk, Vanderstraeten, Alex   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Grading Women's Clothing Patterns with the CAD Pattern System to Improve Student Learning Outcomes and Competencies

Journal of Education Technology, 2020
The purpose of this study is to improve the quality of learning by improving student learning outcomes and competence in grading women’s fashion patterns using the CAD Pattern System learning media.
Umi Kulsum
doaj   +1 more source

Poster Abstracts [PDF]

, 2003
Contents: Lapsley, H., Nikora, L. W., & Black, R. Stigma and discrimination: Bicultural narratives of recovery from disabling mental health illness. Waitoki, M. Cultural Competency Training in Aotearoa.
Black, Rosanne Marjory, Lapsley, Hilary, Levy, Michelle Patricia, Masters-Awatere, Bridgette, Nikora, Linda Waimarie, Pattison, Rosina, Waitoki, Waikaremoana, Williams, Margaret H.   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Relationship Between Student Perceptions of Faculty Support and Student Perceptions of Clinical Competency [PDF]

, 2005
This study explored the relationship between student perceptions of faculty support and student perceptions of clinical competency in beginning and senior level nursing students.
Clark, Linda
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Competence and competence development [PDF]

, 2012
What are today's main concepts and theories - and the main stakes - associated with the issue of competences in organizations? Several topics are discussed, including competence issues regarding the evolution of work, professionalization, competence evaluation, competence management, and the competences of adult educators and trainers, as well as ...
openaire   +2 more sources

Predictive capability of foundational concepts tests for problem-solving using machine learning concepts: Evaluating project-based learning courses in artificial intelligence literacy education

Computers and Education: Artificial Intelligence
In the artificial intelligence (AI) era, secondary and university students should be able to apply AI for problem-solving. This study designed and evaluated an AI literacy programme to enhance understanding of machine learning concepts.
Siu Cheung Kong, Chunyu Hou
doaj   +1 more source