Results 41 to 50 of about 333,512 (299)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Resensi: SDGs Desa, Percepatan Pencapaian Tujuan Pembangunan Nasional Berkelanjutan

open access: yesJurnal Wacana Kinerja, 2021
Buku “SDGs Desa Percepatan Pencapaian Tujuan Pembangunan Nasional Berkelanjutan” ini menyuguhkan gagasan baru dari A. Halim Iskandar selaku Menteri Desa, Pembangunan Daerah Tertinggal dan Transmigrasi tentang konsep Sustainable Development Goals ...
Rosita Novi Andari
doaj  

Building Foresight Capacity: Toward a Foresight Competency Model [PDF]

open access: yes, 2017
This article introduces the Foresight Competency Model, which addresses the basic question of what one ought to be able to do as a professional futurist.
Cornelia Daheim   +7 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Implementasi e-learning di Masa Pandemi Covid-19: Studi Kasus pada Latsar CPNS di Puslatbang PKAN LAN

open access: yesJurnal Wacana Kinerja, 2021
Perkembangan teknologi yang pesat mendorong terjadinya perubahan di berbagai aspek kehidupan. Salah satunya di dunia pendidikan dan pelatihan, di mana model pembelajaran yang sebelumnya banyak dilakukan di dalam kelas (klasikal) atau luar jaringan ...
Yuyu Yuningsih
doaj  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Children’s Participation: Questioning Competence and Competencies?

open access: yesSocial Inclusion, 2017
While Article 12 of the Convention on the Rights of the Child has encouraged children’s participation in collective decision-making, the literature is replete with the challenges as well as successes of such participation. One challenge is adults’ perceptions of children’s competence and competencies. These are frequently used as threshold criteria, so
Le borgne, Carine   +1 more
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Competence and Competence Development [PDF]

open access: yes, 2012
What are today's main concepts and theories - and the main stakes - associated with the issue of competences in organizations? Several topics are discussed, including competence issues regarding the evolution of work, professionalization, competence evaluation, competence management, and the competences of adult educators and trainers, as well as ...
  +6 more sources

Transforming a competency model to parameterised questions in assessment [PDF]

open access: yes, 2009
The problem of comparing and matching different learners’ knowledge arises when assessment systems use a one-dimensional numerical value to represent “knowledge level”.
Lester Gilbert   +5 more
core   +1 more source

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