Results 11 to 20 of about 691,647 (239)

TBI Contusion Segmentation from MRI using Convolutional Neural Networks

, 2018
Traumatic brain injury (TBI) is caused by a sudden trauma to the head that may result in hematomas and contusions and can lead to stroke or chronic disability.
Butman, John A., Chan, Leighton, Pham, Dzung L., Roy, Snehashis   +3 more
core   +1 more source

Generating Factoid Questions With Recurrent Neural Networks: The 30M Factoid Question-Answer Corpus

, 2016
Over the past decade, large-scale supervised learning corpora have enabled machine learning researchers to make substantial advances. However, to this date, there are no large-scale question-answer corpora available.
Ahn, Sungjin, Bengio, Yoshua, Chandar, Sarath, Courville, Aaron, García-Durán, Alberto, Gulcehre, Caglar, Serban, Iulian Vlad   +6 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Market-Oriented Cloud Computing: Vision, Hype, and Reality for Delivering IT Services as Computing Utilities

, 2008
This keynote paper: presents a 21st century vision of computing; identifies various computing paradigms promising to deliver the vision of computing utilities; defines Cloud computing and provides the architecture for creating market-oriented Clouds by ...
Buyya, Rajkumar, Venugopal, Srikumar, Yeo, Chee Shin   +2 more
core   +2 more sources

Modeling competences in enterprise architecture: from knowledge, skills, and attitudes to organizational capabilities

Software and Systems Modeling
AbstractCompetence-based approaches have received increased attention, as the demand for qualified people with the right combination of competences establishes itself as a major factor of organizational performance. This paper examines how competences can be incorporated into Enterprise Architecture modeling: (i) we identify a key set of competence ...
Fernandes Calhau, Rodrigo, Almeida, João Paulo A., Kokkula, Satyanarayana, Guizzardi, Giancarlo   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Learning to Extract Motion from Videos in Convolutional Neural Networks

, 2016
This paper shows how to extract dense optical flow from videos with a convolutional neural network (CNN). The proposed model constitutes a potential building block for deeper architectures to allow using motion without resorting to an external algorithm,
BKP Horn, D Fleet, D Fortun, DJ Butler, DJ Heeger, EH Adelson, F Solari, GW Taylor, KG Derpanis, KG Derpanis, NC Rust, T Brox, T Brox, V Ulman, YA LeCun   +14 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source