Results 111 to 120 of about 2,386,609 (293)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Machine learning photodynamics decode multiple singlet fission channels in pentacene crystal

Nature Communications
Crystalline pentacene is a model solid-state light-harvesting material because its quantum efficiencies exceed 100% via ultrafast singlet fission. The singlet fission mechanism in pentacene crystals is disputed due to insufficient electronic information ...
Zhendong Li, Federico J. Hernández, Christian Salguero, Steven A. Lopez, Rachel Crespo-Otero, Jingbai Li   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Population Synthesis of Accreting Neutron Stars Emitting Gravitational Waves

, 2019
The fastest-spinning neutron stars in low-mass X-ray binaries, despite having undergone millions of years of accretion, have been observed to spin well below the Keplerian break-up frequency.
Andersson, Nils, Gittins, Fabian
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Analysis of Multi-Modal Public Transit Competing Relationships and Evolutionary Mechanisms in Cities in Cold Regions

Applied Sciences
In order to reveal the characteristics of the competition and cooperation of multi-modal public transportation in the cities of cold areas and to study the competitive relationship of multi-modal public transportation in cold areas, the urban public ...
Yulong Pei, Wanjiao Wang
doaj   +1 more source

The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation. [PDF]

Eur Stroke J, 2023
Herlekar R, Sur Roy A, Hajiev S, Induruwa I, Agarwal S, Evans NR, Khadjooi K, Markus H, O'Brien E, Warburton E, Zachariah G, McCabe JJ.   +11 more
europepmc   +1 more source

Exchange coupling in transition-metal nano-clusters on Cu(001) and Cu(111) surfaces

, 2009
We present results of density-functional calculations on the magnetic properties of Cr, Mn, Fe and Co nano-clusters (1 to 9 atoms large) supported on Cu(001) and Cu(111).
Alexander, Antal, Balashov, Bergman, Bergman, Bode, Brovko, Brovko, Etz, Gambardella, Gao, Hafner, Hirjibehedin, Izquierdo, Lau, Lazarovits, Liechtenstein, Lounis, Lounis, Lounis, Lounis, Mankovsky, Mavropoulos, Meier, Minár, Mokrousov, Oswald, Otte, Pajda, Papanikolaou, Polesya, Robles, Spišák, Stepanyuk, Vosko, Weismann, Wildberger, Zener, Šipr   +38 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Argentina Paradox: microexplanations and macropuzzles

Latin American Economic Review, 2018
The economic history of Argentina presents one of the most dramatic examples of divergence in the modern era. What happened and why? This paper reviews the wide range of competing explanations in the literature and argues that, setting aside deeper ...
Alan M. Taylor
doaj   +1 more source