Results 31 to 40 of about 1,084,291 (346)

A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes

Frontiers in Immunology
IntroductionData on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.MethodsWe performed a genome wide association study (GWAS) to identify genes associated with survival/mortality,
Albert Rosenberger, Rachel E. Crossland, Ralf Dressel, Dieter Kube, Daniel Wolff, Gerald Wulf, Heike Bickeböller, Anne Dickinson, Ernst Holler   +8 more
doaj   +1 more source

Crude incidence in two-phase designs in the presence of competing risks. [PDF]

, 2016
BackgroundIn many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies.
A Demnati, AA Tsiatis, AJ Scott, B Langholz, B Langholz, C Särndal, CE Frangakis, David V. Glidden, DG Horvitz, DV Glidden, DY Lin, DY Lin, E Geng, E Marubini, EH Geng, GA Satten, GL Anderson, J Benichou, J Neyman, JP Fine, KE Rudolph, KE Rudolph, Laura Antolini, LC de Wreede, LP Fried, M Wolkewitz, Maria Grazia Valsecchi, N Breslow, NE Breslow, NE Breslow, NP Jewell, OO Aalen, OO Aalen, Paola Rebora, R Core Team, R Franca, RJ Gray, RL Prentice, S Kang, S Kovalchik, SO Samuelsen, T Lumley, TS Lumley, W Barlow, Ø Borgan, Ø Borgan   +45 more
core   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Competing Risks and Multistate Models [PDF]

Clinical Cancer Research, 2013
AbstractComplex clinical endpoints are present in studies in cancer. Especially in studies on hematopoietic stem-cell transplantation (HSCT), various risks exist after HSCT. Patients can experience acute and chronic graft versus host disease (GVHD) or need to undergo immunosuppressive therapy (IST), a relapse can occur, or patients can die after ...
Schmoor, Claudia, Schumacher, Martin, Finke, Jürgen, Beyersmann, Jan   +3 more
openaire   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Missing covariates in competing risks analysis. [PDF]

, 2016
Studies often follow individuals until they fail from one of a number of competing failure types. One approach to analyzing such competing risks data involves modeling the cause-specific hazards as functions of baseline covariates.
Bartlett, Jonathan W, Taylor, Jeremy MG
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Estimation of Employee Turnover with Competing Risks Models

Folia Oeconomica Stetinensia, 2015
Employee turnover accompanies every business organization, regardless of the industry and size. Nowadays, many companies struggle with problems related to the lack of sufficient information about the nature of employee turnover processes.
Grzenda Wioletta, Buczyński Michał K.
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models

BMC Medical Research Methodology, 2021
Background Royston-Parmar flexible parametric survival models (FPMs) can be fitted on either the cause-specific hazards or cumulative incidence scale in the presence of competing risks.
Sarwar I. Mozumder, Mark J. Rutherford, Paul C. Lambert   +2 more
doaj   +1 more source