Results 31 to 40 of about 1,167,728 (343)

A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes

Frontiers in Immunology
IntroductionData on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.MethodsWe performed a genome wide association study (GWAS) to identify genes associated with survival/mortality,
Albert Rosenberger, Rachel E. Crossland, Ralf Dressel, Dieter Kube, Daniel Wolff, Gerald Wulf, Heike Bickeböller, Anne Dickinson, Ernst Holler   +8 more
doaj   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Competing Risks In Mortality Analysis [PDF]

Annual Review of Public Health, 1991
In this paper we present a brief review of the concept of competing risks and the statistical methods of mortality analysis including estimation of three types of probability of dying with respect to a particular cause of death. We will describe formulas of estimates for cohort studies medical follow-up studies and analyses of mortality data for a ...
openaire   +2 more sources

Missing covariates in competing risks analysis. [PDF]

, 2016
Studies often follow individuals until they fail from one of a number of competing failure types. One approach to analyzing such competing risks data involves modeling the cause-specific hazards as functions of baseline covariates.
Bartlett, Jonathan W, Taylor, Jeremy MG
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Estimation of Employee Turnover with Competing Risks Models

Folia Oeconomica Stetinensia, 2015
Employee turnover accompanies every business organization, regardless of the industry and size. Nowadays, many companies struggle with problems related to the lack of sufficient information about the nature of employee turnover processes.
Grzenda Wioletta, Buczyński Michał K.
doaj   +1 more source

Crude incidence in two-phase designs in the presence of competing risks. [PDF]

, 2016
BackgroundIn many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies.
A Demnati, AA Tsiatis, AJ Scott, B Langholz, B Langholz, C Särndal, CE Frangakis, David V. Glidden, DG Horvitz, DV Glidden, DY Lin, DY Lin, E Geng, E Marubini, EH Geng, GA Satten, GL Anderson, J Benichou, J Neyman, JP Fine, KE Rudolph, KE Rudolph, Laura Antolini, LC de Wreede, LP Fried, M Wolkewitz, Maria Grazia Valsecchi, N Breslow, NE Breslow, NE Breslow, NP Jewell, OO Aalen, OO Aalen, Paola Rebora, R Core Team, R Franca, RJ Gray, RL Prentice, S Kang, S Kovalchik, SO Samuelsen, T Lumley, TS Lumley, W Barlow, Ø Borgan, Ø Borgan   +45 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Risks, risk assessment and risk competence in toxicology

German medical science : GMS e-journal, 2015
Das Verständnis der toxischen Wirkungen von Stoffen setzt ein gutes Verständnis der Physiologie bzw. Biochemie voraus. Das häufig beschriebene mangelnde Verständnis in der Bevölkerung für die Pharmakologie und Toxikologie beruht deshalb zu einem großen Teil auf den mangelnden Kenntnissen der erforderlichen Grundlagen.
Stahlmann, R, Horvath, A
openaire   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source