Results 31 to 40 of about 2,145,607 (256)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Estimation of Employee Turnover with Competing Risks Models
Folia Oeconomica Stetinensia, 2015 Employee turnover accompanies every business organization, regardless of the industry and size. Nowadays, many companies struggle with problems related to the lack of sufficient information about the nature of employee turnover processes.
Grzenda Wioletta, Buczyński Michał K.
doaj +1 more source
LocalControl: An R Package for Comparative Safety and Effectiveness Research
Journal of Statistical Software, 2020 The LocalControl R package implements novel approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes.
Nicolas R. Lauve +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Statistical Theory and Related Fields, 2018 In this paper, we consider the statistical analysis for the dependent competing risks model in the constant stress accelerated life testing with Type-II progressive censoring. It is focused on two competing risks from Lomax distribution.
Xuchao Bai +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2022 Objectives: To examine the predictive performance for placental dysfunction related stillbirths of the competing risks model for small-for-gestational-age (SGA) fetuses based on fetusa combination of maternal risk factors, estimated fetal weight
Papastefanou, I. +4 more
core +1 more source
A copula model for dependent competing risks [PDF]
"Many popular estimators for duration models require independent competing risks or independent censoring. In contrast, copula based estimators are also consistent in presence of dependent competing risks.
Wilke, Ralf A., Lo, Simon M. S.
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Revista Colombiana de Estadística, 2011 The identifiability problem in competing risks associated to the dependence measure between the failure modes, can be solved by means of the copula-graphic estimator which assumes the copula function known. This paper compares, through a simulation study,
Yáñez Sergio +3 more
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