Results 31 to 40 of about 514,439 (307)

Competing Risks and Multistate Models [PDF]

Clinical Cancer Research, 2013
Abstract Complex clinical endpoints are present in studies in cancer. Especially in studies on hematopoietic stem-cell transplantation (HSCT), various risks exist after HSCT. Patients can experience acute and chronic graft versus host disease (GVHD) or need to undergo immunosuppressive therapy (IST), a relapse can occur, or patients ...
Schmoor, Claudia, Schumacher, Martin, Finke, Jürgen, Beyersmann, Jan   +3 more
openaire   +3 more sources

Predictive performance for placental dysfunction related stillbirth of the competing risks model for small‐for‐gestational‐age fetuses

, 2022
Objectives: To examine the predictive performance for placental dysfunction related stillbirths of the competing risks model for small-for-gestational-age (SGA) fetuses based on fetusa combination of maternal risk factors, estimated fetal weight
Papastefanou, I., Nicolaides, Kypros H., Akolekar, Ranjit, Ashoor, Ghalia, Syngelaki, Argyro   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling competing risks data by a bivariate model with singularity originating from a shock model using the Lehmann family of distributions

Research in Statistics
In this article, a general family of bivariate distributions is used to model competing risks data with dependent causes. The general structure of competing risks data considered here includes ties.
Aakash Agrawal, Ayon Ganguly, Debanjan Mitra   +2 more
doaj   +1 more source

Statistical analysis of dependent competing risks model in constant stress accelerated life testing with progressive censoring based on copula function

Statistical Theory and Related Fields, 2018
In this paper, we consider the statistical analysis for the dependent competing risks model in the constant stress accelerated life testing with Type-II progressive censoring. It is focused on two competing risks from Lomax distribution.
Xuchao Bai, Yimin Shi, Yiming Liu, Bin Liu   +3 more
doaj   +1 more source

LocalControl: An R Package for Comparative Safety and Effectiveness Research

Journal of Statistical Software, 2020
The LocalControl R package implements novel approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes.
Nicolas R. Lauve, Stuart J. Nelson, S. Stanley Young, Robert L. Obenchain, Christophe G. Lambert   +4 more
doaj   +1 more source

Weighted Competing Risks Quantile Regression Models and Variable Selection

Mathematics, 2023
The proportional subdistribution hazards (PSH) model is popularly used to deal with competing risks data. Censored quantile regression provides an important supplement as well as variable selection methods due to large numbers of irrelevant covariates in
Erqian Li, Jianxin Pan, Manlai Tang, Keming Yu, Wolfgang Karl Härdle, Xiaowen Dai, Maozai Tian   +6 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Dipolar Tree Ensemble With and Without Adjustment to Competing Risks: Application to Medical Data

Studies in Logic, Grammar and Rhetoric, 2013
The analysis of survival data often aims at the prediction of failure time distribution. In cases of competing risk events, the time distributions of more than one failure are under investigation.
Krętowska Małgorzata
doaj   +1 more source