Results 31 to 40 of about 1,183,596 (299)

Modelling competing risks data by a bivariate model with singularity originating from a shock model using the Lehmann family of distributions

Research in Statistics
In this article, a general family of bivariate distributions is used to model competing risks data with dependent causes. The general structure of competing risks data considered here includes ties.
Aakash Agrawal, Ayon Ganguly, Debanjan Mitra   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Statistical analysis and application of competing risks model with regression

Croatian Operational Research Review, 2019
The paper deals with the methods of statistical analysis of dependent competing risks in the presence of covariates. The problem of identification of marginal and joint distributions of competing random variables is recalled and certain ...
Petr Volf
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Crude incidence in two-phase designs in the presence of competing risks. [PDF]

, 2016
BackgroundIn many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies.
A Demnati, AA Tsiatis, AJ Scott, B Langholz, B Langholz, C Särndal, CE Frangakis, David V. Glidden, DG Horvitz, DV Glidden, DY Lin, DY Lin, E Geng, E Marubini, EH Geng, GA Satten, GL Anderson, J Benichou, J Neyman, JP Fine, KE Rudolph, KE Rudolph, Laura Antolini, LC de Wreede, LP Fried, M Wolkewitz, Maria Grazia Valsecchi, N Breslow, NE Breslow, NE Breslow, NP Jewell, OO Aalen, OO Aalen, Paola Rebora, R Core Team, R Franca, RJ Gray, RL Prentice, S Kang, S Kovalchik, SO Samuelsen, T Lumley, TS Lumley, W Barlow, Ø Borgan, Ø Borgan   +45 more
core   +3 more sources

Competing risks and the risks of children and adults competing for livers [PDF]

American Journal of Transplantation, 2021
Paul A. MacLennan, Babak J. Orandi
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes

Frontiers in Immunology
IntroductionData on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.MethodsWe performed a genome wide association study (GWAS) to identify genes associated with survival/mortality,
Albert Rosenberger, Rachel E. Crossland, Ralf Dressel, Dieter Kube, Daniel Wolff, Gerald Wulf, Heike Bickeböller, Anne Dickinson, Ernst Holler   +8 more
doaj   +1 more source

Estimation of Employee Turnover with Competing Risks Models

Folia Oeconomica Stetinensia, 2015
Employee turnover accompanies every business organization, regardless of the industry and size. Nowadays, many companies struggle with problems related to the lack of sufficient information about the nature of employee turnover processes.
Grzenda Wioletta, Buczyński Michał K.
doaj   +1 more source