Results 41 to 50 of about 1,084,291 (346)

Modelling competing risks in nephrology research: an example in peritoneal dialysis [PDF]

, 2013
BACKGROUND: Modelling competing risks is an essential issue in Nephrology Research. In peritoneal dialysis studies, sometimes inappropriate methods (i.e.
Cabrita, A., Carvalho, M., Mendonça, D., Rodrigues, A., Teixeira, L.   +4 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

COMPARISON BETWEEN COMPETING RISKS VIA THE COPULA-GRAPHIC ESTIMATOR COMPARACIÓN ENTRE RIESGOS COMPETITIVOS VÍA EL ESTIMADOR CÓPULA-GRÁFICO

Revista Colombiana de Estadística, 2011
The identifiability problem in competing risks associated to the dependence measure between the failure modes, can be solved by means of the copula-graphic estimator which assumes the copula function known. This paper compares, through a simulation study,
Yáñez Sergio, Brango Hugo, Jaramillo Mario C., Lopera Carlos M.   +3 more
doaj  

Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19

Life, 2023
Methodological biases are common in observational studies evaluating treatment effectiveness. The objective of this study is to emulate a target trial in a competing risks setting using hospital-based observational data. We extend established methodology
Oksana Martinuka, Maja von Cube, Derek Hazard, Hamid Reza Marateb, Marjan Mansourian, Ramin Sami, Mohammad Reza Hajian, Sara Ebrahimi, Martin Wolkewitz   +8 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Comparación entre riesgos competitivos vía el estimador cópula-gráfico

Revista Colombiana de Estadística, 2011
En riesgos competitivos, el problema de identificabilidad asociado a la dependencia entre los modos de falla, se puede resolver utilizando el estimador cópula-gráfico que asume la forma de la cópula conocida.
SERGIO YÁÑEZ, HUGO BRANGO, MARIO C. JARAMILLO, CARLOS M. LOPERA   +3 more
doaj  

Estimating disease incidence rates and transition probabilities in elderly patients using multi-state models: a case study in fragility fracture using a Bayesian approach

BMC Medical Research Methodology, 2023
Background Multi-state models are complex stochastic models which focus on pathways defined by the temporal and sequential occurrence of numerous events of interest.
Fran Llopis-Cardona, Carmen Armero, Gabriel Sanfélix-Gimeno   +2 more
doaj   +1 more source

Competing risks and the risks of children and adults competing for livers [PDF]

American Journal of Transplantation, 2021
Paul A. MacLennan, Babak J. Orandi
openaire   +2 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

APPLICATION OF THE RECURRENT DATA ANALYSIS ON FL245 SWITCHES AT INTERCONEXIÓN ELÉCTRICA S.A. APLICACIÓN DEL ANÁLISIS DE DATOS RECURRENTES SOBRE INTERRUPTORES FL245 EN INTERCONEXIÓN ELÉCTRICA S.A.

Revista Colombiana de Estadística, 2011
Recurrent data arise when a unit (or group of such units) is monitored over time and a particular event (or group of events) occurs at several points of the observation period, for example, times of recurrent episodes of a disease in patients or times of
Lopera Carlos M., Manotas Eva Cristina
doaj