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COMPARISON BETWEEN COMPETING RISKS VIA THE COPULA-GRAPHIC ESTIMATOR COMPARACIÓN ENTRE RIESGOS COMPETITIVOS VÍA EL ESTIMADOR CÓPULA-GRÁFICO

open access: yesRevista Colombiana de Estadística, 2011
The identifiability problem in competing risks associated to the dependence measure between the failure modes, can be solved by means of the copula-graphic estimator which assumes the copula function known. This paper compares, through a simulation study,
Yáñez Sergio   +3 more
doaj  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Comparación entre riesgos competitivos vía el estimador cópula-gráfico

open access: yesRevista Colombiana de Estadística, 2011
En riesgos competitivos, el problema de identificabilidad asociado a la dependencia entre los modos de falla, se puede resolver utilizando el estimador cópula-gráfico que asume la forma de la cópula conocida.
SERGIO YÁÑEZ   +3 more
doaj  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

APPLICATION OF THE RECURRENT DATA ANALYSIS ON FL245 SWITCHES AT INTERCONEXIÓN ELÉCTRICA S.A. APLICACIÓN DEL ANÁLISIS DE DATOS RECURRENTES SOBRE INTERRUPTORES FL245 EN INTERCONEXIÓN ELÉCTRICA S.A.

open access: yesRevista Colombiana de Estadística, 2011
Recurrent data arise when a unit (or group of such units) is monitored over time and a particular event (or group of events) occurs at several points of the observation period, for example, times of recurrent episodes of a disease in patients or times of
Lopera Carlos M., Manotas Eva Cristina
doaj  

Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models

open access: yesBMC Medical Research Methodology, 2021
Background Royston-Parmar flexible parametric survival models (FPMs) can be fitted on either the cause-specific hazards or cumulative incidence scale in the presence of competing risks.
Sarwar I. Mozumder   +2 more
doaj   +1 more source

Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19

open access: yesLife, 2023
Methodological biases are common in observational studies evaluating treatment effectiveness. The objective of this study is to emulate a target trial in a competing risks setting using hospital-based observational data. We extend established methodology
Oksana Martinuka   +8 more
doaj   +1 more source

Modelling competing risks in nephrology research: an example in peritoneal dialysis [PDF]

open access: yes, 2013
BACKGROUND: Modelling competing risks is an essential issue in Nephrology Research. In peritoneal dialysis studies, sometimes inappropriate methods (i.e.
Cabrita, A.   +4 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

The importance of censoring in competing risks analysis of the subdistribution hazard

open access: yesBMC Medical Research Methodology, 2017
Background The analysis of time-to-event data can be complicated by competing risks, which are events that alter the probability of, or completely preclude the occurrence of an event of interest.
Mark W. Donoghoe, Val Gebski
doaj   +1 more source

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