Results 131 to 140 of about 4,025,054 (343)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Impacts of hydraulic redistribution on grass–tree competition vs facilitation in a semi‐arid savanna [PDF]

, 2017
Greg A. Barron‐Gafford, Enrique P. Sánchez‐Cañete, R. L. Minor, Sean M. Hendryx, Esther Lee, Leland F. Sutter, Newton Tran, Elizabeth Ann Parra, Tony Colella, Patrick Murphy, Erik P. Hamerlynck, Praveen Kumar, Russell L. Scott   +12 more
openalex   +1 more source

The Spatial Spillover Effects of Environmental Regulation and Regional Energy Efficiency and Their Interactions under Local Government Competition in China [PDF]

, 2022
Fangyu Ju, Mengfan Ke
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The Growth of Leading Regional Newspapers

Nordicom Review, 2014
Theoretical research has modelled the existence of so-called advertising-circulation spirals of newspapers. The present article examines the existence and shape of the growth functions of circulation for leading regional newspapers in Finland, and ...
Björkroth Tom, Grönlund Mikko
doaj   +1 more source

Tree potential growth varies more than competition among spontaneously established forest stands of pedunculate oak (Quercus robur) [PDF]

, 2020
Dominique Lamonica, Jörn Pagel, Elena Valdés‐Correcher, Didier Bert, Arndt Hampe, Frank M. Schurr   +5 more
openalex   +1 more source

Intraspecific variation in metal tolerance modulate competition between two marine diatoms [PDF]

, 2021
Björn Andersson, Anna Godhe, Helena L. Filipsson, Linda Zetterholm, Lars Edler, Olof Berglund, Karin Rengefors   +6 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Competition [PDF]

Competition has been modelled in the literature in a number of ways.What do these different parametrizations of competition have in common?For instance, it turns out that it is not always the case that a rise in competition reduces price cost margins ...
Boone, J.
core   +1 more source