Results 111 to 120 of about 2,499,667 (343)

Genetic differentiation of prey predator interaction model along with an Holling type-II functional response

Partial Differential Equations in Applied Mathematics
Prey–predator models play a vital role in mathematical biology. The competition that evolves between them is addressed in a broad scenario. According to genetics theory, various specie’s genotypes yield different outcomes in competition.
G. Santhosh Kumar, C. Gunasundari, Salah Mahmoud Boulaaras, M. Aakash, N.B. Sharmila   +4 more
doaj   +1 more source

Gene Regulatory Network Inference: Connecting Plant Biology and Mathematical Modeling

Frontiers in Genetics, 2020
Plant responses to environmental and intrinsic signals are tightly controlled by multiple transcription factors (TFs). These TFs and their regulatory connections form gene regulatory networks (GRNs), which provide a blueprint of the transcriptional ...
Lisa Van den Broeck, Max Gordon, D. Inzé, Cranos M. Williams, Rosangela Sozzani   +4 more
semanticscholar   +1 more source

Darwinian Adverse Selection

, 2015
We develop a model to study the role of rationality in economics and biology. The model's agents differ continuously in their ability to make rational choices.
Kuhle, Wolfgang
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Sportwissenschaft

Deutsche Zeitschrift für Sportmedizin, 2016
We assessed whetherthe seasonal training pattern of endurance athletes produces corresponding adaptations of mitochondrial, angiogenic, and myogenic processes in skeletal muscle and whether these relate to the training volume and metabolic load during ...
Frese S, 2, Valdivieso P, Jaecker VC, Harms SA, Konou TM, Tappe KA, Schiffer T, Frese L, Bloch W, 6, Flück M, 7   +12 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Food Quality in Producer-Grazer Models: A Generalized Analysis

, 2010
Stoichiometric constraints play a role in the dynamics of natural populations, but are not explicitly considered in most mathematical models. Recent theoretical works suggest that these constraints can have a significant impact and should not be ...
Feudel, Ulrike, Gross, Thilo, Kooi, Bob W., Stiefs, Dirk, van Voorn, George A. K.   +4 more
core   +2 more sources

Probing the limits to microRNA-mediated control of gene expression [PDF]

, 2016
According to the `ceRNA hypothesis', microRNAs (miRNAs) may act as mediators of an effective positive interaction between long coding or non-coding RNA molecules, carrying significant potential implications for a variety of biological processes.
De Martino, Andrea, Figliuzzi, Matteo, Marinari, Enzo, Martirosyan, Araks   +3 more
core   +6 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source