Results 111 to 120 of about 747,285 (331)
Frontiers in Bioengineering and BiotechnologySynthetic biology is an interdisciplinary field that brings together engineering and biology concepts alongside the arts and social sciences to develop solutions to pressing problems in our world.
Iain George +9 more
doaj +1 more source
Synthetic biology and biosecurity: challenging the ‘myths’
Frontiers in Public Health, 2014 Synthetic biology, a field that aims to ‘make biology easier to engineer’, is routinely described as leading to an increase in the ‘dual use’ threat, i.e.
Catherine eJefferson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Receptor uptake arrays for vitamin B12, siderophores and glycans shape bacterial communities
, 2017 Molecular variants of vitamin B12, siderophores and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe Bacteroides thetaiotaomicron has three different receptors to take up variants of vitamin B12 and 88 ...
Frank, Steven A.
core +1 more source
How should novelty be valued in science? [PDF]
, 2014 Box plot analysis of serum concentrations of sRAGE (A), esRAGE (B), S100A9 (C) and HMGB1 (D) in patients with CTEPH (n = 26) and controls (n = 33). Independent Student’s t-test was used to compare groups. RAGE receptor for advanced glycation endproducts,
Ana-Iris Schiefer (547363) +13 more
core +4 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Coexistence and relative abundance in annual plant assemblages: The roles of competition and colonization [PDF]
, 2002 Although an interspecific trade-off between competitive and colonizing ability can permit multispecies coexistence, whether this mechanism controls the structure of natural systems remains unresolved.
Levine, J.M., Rees, M.
core
Stochastic and deterministic models for age-structured populations with genetically variable traits
, 2009 Understanding how stochastic and non-linear deterministic processes interact is a major challenge in population dynamics theory. After a short review, we introduce a stochastic individual-centered particle model to describe the evolution in continuous ...
C. Besse +5 more
core +3 more sources
Evolution of Helping and Harming in Viscous Populations When Group Size Varies [PDF]
, 2013 Funding: Balliol College and the Royal Society.Recent years have seen huge interest in understanding how demographic factors mediate the evolution of social behavior in viscous populations.
Gardner, Andy, Rodrigues, Antonio M. M.
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source