Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
The Single Market and EU Competition Law - Two Pillars of the European Union [PDF]
Global Economic Observer, 2014 The interplay between a deeper, broader, well-functioning Single Market and an active and efficient enforcement of EU competition law is at the core of higher productivity and sustainable growth across Europe.
LUCIA IORDACHE
doaj
South African competition policy on excessive pricing and its relation to price gouging during the COVID-19 disaster period. [PDF]
S Afr J Econ, 2021 Boshoff WH.
europepmc +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Implications of the EU Multi-Level Governance in the Field of Competition Policy – A Comparative Analysis of the Characteristics of Cohesion and Competition Policies [PDF]
Romanian Journal of European Affairs, 2011 The paper aims at analyzing the intrinsic characteristics of the European Union and to show that these characteristics objectively require the implementation of multi-level governance.
Florin Bonciu
doaj
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Competition Policy: Administrative-Territorial Aspect
Управленческое консультирование, 2018 In this article the analysis of validity and expediency of improvement of the mechanism of realization of a competition policy on more isolated territorial units, such as is offered: territorial subject of the Russian Federation, municipal territorial ...
Artem Vladimirovich Polenov
doaj
European Competition Policy in time of crisis. To be or not to be
Studies and Scientific Researches: Economics Edition, 2009 It is a known fact that Competition and all the policies implied by it have a positive impact on Economy. But what happens when financial crisis strike?
Liviana Niminet
doaj +1 more source
Outsourcing and Competition Policy [PDF]
We analyze optimal competition policy by a Competition Agency (CA) in a model with two countries, North and South, where a final good is produced by Northern oligopolistic firms using an input that can either be produced within the firm (vertical ...
Cosimo Beverelli Kornel Mahlstein
core
Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands
Advanced Science, EarlyView.Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang +9 more
wiley +1 more source