Results 91 to 100 of about 1,029,116 (295)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Competitive Intensity as Driver of Innovation and Productivity Growth: A Synthesis of the Literature [PDF]

The objective of the report is to survey and assess the existing economic theoretical literature and empirical evidence on the linkages between open and competitive markets (competitive intensity) and innovation and productivity growth.
Andrew Sharpe, Ian Currie
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Competitive dynamics in the international airline market: Exploring antecedents of competitive actions

Transport Economics and Management
When airlines engage in competitive actions against each other, they are expected to do so for a variety of reasons. Although the ultimate goal of these competitive actions is to increase market share against competitors and to achieve above-average ...
Mehmet Yasar, Ender Gerede
doaj   +1 more source

Individual chronobiological regularity in track-and-field sprint

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2018
The purpose of the work: to identify the patterns of individual dynamics of competitive performance in track and field sprint. Material. The study involved a highly qualified athlete (running for short distances, long jumps). Results. In the sinusoidal
Zh.L. Kozina, I.F. Prokopenko, M. Cretu, O.I. Chaika, O.A. Ryepko, A.V. Osiptsov, T.O. Razumenko, M.D. Kudryavtsev, A.O. Polianskyi   +8 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Competitive oscillatory dynamics in excitable neuron networks

Frontiers in Network Physiology
Collective dynamics of networks of excitable neurons can be considered as the emergence of ordering from microscopic self-organization at the macroscopic scale.
Zhigang Zheng, Zhigang Zheng, Lin Yan, Lin Yan, Tao Li, Tao Li, Jiajing Liu, Jiajing Liu, Lei Wang, Lei Wang, Yu Qian   +10 more
doaj   +1 more source

Resilience Capacity and Strategic Agility: Prerequisites for Thriving in a Dynamic Environment [PDF]

organizational resilience, strategic agility, competitive ...
Cynthia A. Lengnick-Hall, Tammy E. Beck
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Estimación de un modelo econométrico para determinar el efecto de acciones de marketing en ventas de productos de cuidado personal en Colombia // Panel Analysis to Determine the Effect of Marketing Actions on Sales of Personal Care Products

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2016
Este estudio tiene el objetivo de mostrar a los profesionales del área del marketing cómo se pueden emplear modelos econométricos de panel para realizar un análisis de las acciones de marketing.
Ana M. Arboleda, Julio C. Alonso
doaj