Results 91 to 100 of about 317,143 (313)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Strategies for appropriate technology and competitive performance in infrastructure construction
, 1994 Earlier research developed theoretically-based aggregate metrics for technology strategy and used them to analyze California bridge construction firms (Hampson, 1993). Determinants of firm performance, including trend in contract awards, market share and
Hampson, Keith D., Tatum, C. Bob
core
Cogent Business & Management, 2017 This paper explores how the choices about, and implementation of, lean production practices are influenced by performance goals prioritized by firms in the context of operations strategy.
Hamilton Pozo +2 more
doaj +1 more source
The harmonized effects of generic strategies and business capabilities on business performance
Journal of Business Economics and Management, 2010 Resource‐based view and the positioning theory are the two main approaches which are considered as contrary to each other in order to achieve competitive advantage and superior business performance.
Avni Zafer Acar, Cemal Zehir
doaj +1 more source
Diversity of bacterial small RNAs drives competitive strategies for a mutual chaperone. [PDF]
Nat Commun, 2022 Roca J, Santiago-Frangos A, Woodson SA.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Gestão & Produção, 1999 As mudanças no ambiente institucionais e seus efeitos sobre o desempenho recente da produção de milho e soja no Brasil e Argentina são os objetivos deste artigo, que tem como referencial teórico a Nova Economia das Instituições.
Eduardo Luis Leão de Sousa +2 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
THE INFLUENCE OF THE COMPETITIVE ENVIRONMENT ON THE COMPANIES COMPETITIVENESS [PDF]
In a market economy, competition is the engine which makes the entire system of connections between the economic operators work, the main element of the market mechanism which leads to the development of the economic life.
Assoc. Prof. Laurențiu Constantin Dragomir Ph. D +1 more
core
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source